The 2011 CAF Champions League knock-out stage matches took place between September and November 2011. The matchdays were: 30 September–2 October (semifinals first leg), 14–16 October (semifinals second leg), 4–6 November (final first leg), 11–13 November (final second leg).[1]
All knock-out ties were decided over two legs, with aggregate goals used to determine the winner. If the sides were level on aggregate after the second leg, the away goals rule applied, and if still level, the tie proceeded directly to a penalty shootout (no extra time is played).[2]
The knock-out stage featured four teams: the two group winners and the two group runners-up from the group stage. In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up. In both ties, the group winners hosted the second leg at home.[2]
| Group | Winners | Runners-up |
|---|---|---|
| A |  Enyimba
|
 Al-Hilal
|
| B |  Espérance ST
|
 Wydad AC
|
| Wydad AC | 1 – 0 | Enyimba |
|---|---|---|
Pascal Angan  89' |
Report |
Wydad AC won 1–0 on aggregate and advanced to the 2011 CAF Champions League Final.
| Espérance ST | 2 – 0 | Al-Hilal |
|---|---|---|
| Youssef Msakni 52' Wajdi Bouazzi 90' |
Report |
Espérance ST won 3–0 on aggregate and advanced to the 2011 CAF Champions League Final.
|
Main article: 2011 CAF Champions League Final |
| Wydad AC | 0 – 0 | Espérance ST |
|---|---|---|
| Report |
| Espérance ST | 1 – 0 | Wydad AC |
|---|---|---|
| Harrison Afful 18' |
Report |
Espérance ST won 1–0 on aggregate.