Clemson completed their regular season with a 9–3 overall record, 6–2 in ACC games. The Tigers suffered two losses in their first four games, and did not reach the ACC Championship Game for the first time since the 2014 season. Clemson played three ranked teams during the regular season, losing to Georgia and Pittsburgh while defeating Wake Forest.
Iowa State completed their regular season with an overall 7–5 record, 5–4 in Big 12 games. The Cyclones also lost two of their first four games, and later finished the season by losing three of their final five games. Iowa State faced three ranked FBS teams during the regular season, losing to Iowa and Oklahoma while defeating Oklahoma State.