The 2021 Mississippi College Choctaws football team represented Mississippi College as a member of the Gulf South Conference (GSC) during the 2021 NCAA Division II football season. They were led by eighth-year head coach John Bland. The Choctaws played their home games at Robinson-Hale Stadium in Clinton, Mississippi.

Schedule

Mississippi College announced their 2021 football schedule on August 3, 2021.^[1]

Date	Time	Opponent	Site	TV	Result	Attendance
September 2	6:00 p.m.	Albany State*	Robinson-Hale Stadium Clinton, MS		L 0–24	3,134
September 18	2:00 p.m.	Fort Lauderdale*	Robinson–Hale Stadium Clinton, MS		W 63–0	2,879
September 25	7:00 p.m.	No. 21 West Alabama	Robinson–Hale Stadium Clinton, MS	FloSports	L 28–31	2,954
October 2	2:00 p.m.	at North Greenville	Younts Stadium Tigerville, SC	FloSports	W 42–21	3,421
October 9	2:00 p.m.	No. 13 West Georgia	Robinson–Hale Stadium Clinton, MS	FloSports	L 21–40	3,278
October 16	12:00 p.m.	at Shorter	Barron Stadium Rome, GA	FloSports	W 20–7	1,521
October 23	2:00 p.m.	No. 2 Valdosta State	Robinson–Hale Stadium Clinton, MS	FloSports	L 14–41	1,256
October 30	6:00 p.m.	No. 5 West Florida	Robinson–Hale Stadium Clinton, MS	FloSports	L 28–63	4,238
November 6	2:00 p.m.	at Delta State	McCool Stadium Cleveland, MS (rivalry)	FloSports	L 21–24 OT	3,768
November 13	12:00 p.m.	at West Alabama [1]*	Tiger Stadium Livingston, AL	FloSports	W 28–24	2,491
*Non-conference game Homecoming Rankings from AFCA Poll released prior to the game All times are in Central time