Combination of | |
---|---|
Cagrilintide | Amylin receptor agonist |
Semaglutide | GLP-1 receptor agonist |
Clinical data | |
Trade names | CagriSema |
Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is injected once weekly and is being tested in type 2 diabetes and obesity. Preliminary trial results found a greater weight loss compared to either medication alone. HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone.[1][2] In a Phase II trial, weight loss averaged -15.6 percent after 32 weeks, making CagriSema comparable in efficacy to tirzepatide.[3][4] A future trial sponsored by Novo Nordisk is comparing tirzepatide and CagriSema head-to-head.[5] As of 2023, CagriSema is in a Phase III trial.[6]