The Chamberlayne Baronetcy of Wickham, Oxfordshire was created for Thomas Chamberlayne in the Baronetage of England on 4 February 1603. He was appointed High Sheriff of Oxfordshire for 1643.
Chamberlayne Baronets of Wickham, Oxfordshire (1603)
- Sir Thomas Chamberlayne, 1st Baronet (died 6 Oct 1643)
- Revd Sir Thomas Chamberlayne, 2nd Baronet (c.1635–1682)
- Sir James Chamberlayne, 3rd Baronet (c.1640–Oct 1694)
- Sir James Chamberlayne, 4th Baronet (died 23 Dec 1767)
- Sir Henry Chamberlayne, 5th Baronet (died 25 Jan 1776) Baronetcy extinct on his death.
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