Protein-coding gene in the species Homo sapiens
FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.[5][6][7]
Function
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[8][7]
Interactions
FKBP3 has been shown to interact with YY1,[9] HDAC1,[9] Histone deacetylase 2,[9] DNA,[10] and Mdm2.[11] Both crystal structure of FKBP25 with FK506 and the NMR structure of full length FKBP25 has been published with PDB ID 5D75 and 2MPH respectively.[8][12]