This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.^[1] The database is developed and maintained by Andrew McDonald.^[2]

EC 4.1: Carbon-Carbon Lyases

EC 4.1.1: Carboxy-lyases

EC 4.1.1.1: pyruvate decarboxylase
EC 4.1.1.2: oxalate decarboxylase
EC 4.1.1.3: Now recognized to be two enzymes EC 7.2.4.2 [oxaloacetate decarboxylase (Na⁺ extruding)] and EC 4.1.1.112 (oxaloacetate decarboxylase).
EC 4.1.1.4: acetoacetate decarboxylase
EC 4.1.1.5: acetolactate decarboxylase
EC 4.1.1.6: cis-aconitate decarboxylase
EC 4.1.1.7: benzoylformate decarboxylase
EC 4.1.1.8: oxalyl-CoA decarboxylase
EC 4.1.1.9: malonyl-CoA decarboxylase
EC 4.1.1.10: Now included with EC 4.1.1.12, aspartate 4-decarboxylase
EC 4.1.1.11: aspartate 1-decarboxylase
EC 4.1.1.12: aspartate 4-decarboxylase
EC 4.1.1.13: deleted
EC 4.1.1.14: valine decarboxylase
EC 4.1.1.15: glutamate decarboxylase
EC 4.1.1.16: hydroxyglutamate decarboxylase
EC 4.1.1.17: ornithine decarboxylase
EC 4.1.1.18: lysine decarboxylase
EC 4.1.1.19: arginine decarboxylase
EC 4.1.1.20: diaminopimelate decarboxylase
EC 4.1.1.21: phosphoribosylaminoimidazole carboxylase
EC 4.1.1.22: histidine decarboxylase
EC 4.1.1.23: orotidine-5′-phosphate decarboxylase
EC 4.1.1.24: aminobenzoate decarboxylase
EC 4.1.1.25: tyrosine decarboxylase
EC 4.1.1.26: Now included with EC 4.1.1.28 aromatic-L-amino-acid decarboxylase
EC 4.1.1.27: Now included with EC 4.1.1.28 aromatic-L-amino-acid decarboxylase
EC 4.1.1.28: aromatic-L-amino-acid decarboxylase
EC 4.1.1.29: sulfoalanine decarboxylase
EC 4.1.1.30: pantothenoylcysteine decarboxylase
EC 4.1.1.31: phosphoenolpyruvate carboxylase
EC 4.1.1.32: phosphoenolpyruvate carboxykinase (GTP)
EC 4.1.1.33: diphosphomevalonate decarboxylase
EC 4.1.1.34: dehydro-L-gulonate decarboxylase
EC 4.1.1.35: UDP-glucuronate decarboxylase
EC 4.1.1.36: phosphopantothenoylcysteine decarboxylase
EC 4.1.1.37: uroporphyrinogen decarboxylase
EC 4.1.1.38: phosphoenolpyruvate carboxykinase (diphosphate)
EC 4.1.1.39: ribulose-bisphosphate carboxylase
EC 4.1.1.40: hydroxypyruvate decarboxylase
EC 4.1.1.41: Now EC 7.2.4.3, (S)-methylmalonyl-CoA decarboxylase
EC 4.1.1.42: carnitine decarboxylase
EC 4.1.1.43: phenylpyruvate decarboxylase
EC 4.1.1.44: 4-carboxymuconolactone decarboxylase
EC 4.1.1.45: aminocarboxymuconate-semialdehyde decarboxylase
EC 4.1.1.46: o-pyrocatechuate decarboxylase
EC 4.1.1.47: tartronate-semialdehyde synthase
EC 4.1.1.48: indole-3-glycerol-phosphate synthase
EC 4.1.1.49: phosphoenolpyruvate carboxykinase (ATP)
EC 4.1.1.50: adenosylmethionine decarboxylase
EC 4.1.1.51: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
EC 4.1.1.52: 6-methylsalicylate decarboxylase
EC 4.1.1.53: phenylalanine decarboxylase
EC 4.1.1.54: dihydroxyfumarate decarboxylase
EC 4.1.1.55: 4,5-dihydroxyphthalate decarboxylase
EC 4.1.1.56: 3-oxolaurate decarboxylase
EC 4.1.1.57: methionine decarboxylase
EC 4.1.1.58: orsellinate decarboxylase
EC 4.1.1.59: gallate decarboxylase
EC 4.1.1.60: stipitatonate decarboxylase
EC 4.1.1.61: 4-hydroxybenzoate decarboxylase
EC 4.1.1.62: gentisate decarboxylase
EC 4.1.1.63: protocatechuate decarboxylase
EC 4.1.1.64: 2,2-dialkylglycine decarboxylase (pyruvate)
EC 4.1.1.65: phosphatidylserine decarboxylase
EC 4.1.1.66: uracil-5-carboxylate decarboxylase
EC 4.1.1.67: UDP-galacturonate decarboxylase
EC 4.1.1.68: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
EC 4.1.1.69: 3,4-dihydroxyphthalate decarboxylase
EC 4.1.1.70: Now EC 7.2.4.5, glutaconyl-CoA decarboxylase
EC 4.1.1.71: 2-oxoglutarate decarboxylase
EC 4.1.1.72: branched-chain-2-oxoacid decarboxylase
EC 4.1.1.73: tartrate decarboxylase
EC 4.1.1.74: indolepyruvate decarboxylase
EC 4.1.1.75: 5-guanidino-2-oxopentanoate decarboxylase
EC 4.1.1.76: arylmalonate decarboxylase
EC 4.1.1.77: 4-oxalocrotonate decarboxylase
EC 4.1.1.78: acetylenedicarboxylate decarboxylase
EC 4.1.1.79: sulfopyruvate decarboxylase
EC 4.1.1.80: 4-hydroxyphenylpyruvate decarboxylase
EC 4.1.1.81: threonine-phosphate decarboxylase
EC 4.1.1.82: phosphonopyruvate decarboxylase
EC 4.1.1.83: 4-hydroxyphenylacetate decarboxylase
EC 4.1.1.84: D-dopachrome decarboxylase
EC 4.1.1.85: 3-dehydro-L-gulonate-6-phosphate decarboxylase
EC 4.1.1.86: diaminobutyrate decarboxylase
EC 4.1.1.87: malonyl-S-ACP decarboxylase
EC 4.1.1.88: biotin-independent malonate decarboxylase
EC 4.1.1.89: Now EC 7.2.4.4 EC 7.2.4.4, biotin-dependent malonate decarboxylase
EC 4.1.1.90: peptidyl-glutamate 4-carboxylase
EC 4.1.1.91: salicylate decarboxylase
EC 4.1.1.92: indole-3-carboxylate decarboxylase
EC 4.1.1.93: pyrrole-2-carboxylate decarboxylase
EC 4.1.1.94: ethylmalonyl-CoA decarboxylase
EC 4.1.1.95: L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
EC 4.1.1.96: carboxynorspermidine decarboxylase
EC 4.1.1.97: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase *
EC 4.1.1.98: 4-hydroxy-3-polyprenylbenzoate decarboxylase *
EC 4.1.1.99: phosphomevalonate decarboxylase *
EC 4.1.1.100: prephenate decarboxylase *
EC 4.1.1.101: malolactic enzyme *
EC 4.1.1.102: phenacrylate decarboxylase *
EC 4.1.1.103: γ-resorcylate decarboxylase *
EC 4.1.1.104: 3-dehydro-4-phosphotetronate decarboxylase *
EC 4.1.1.105: L-tryptophan decarboxylase *
EC 4.1.1.106: fatty acid photodecarboxylase
EC 4.1.1.107: 3,4-dihydroxyphenylacetaldehyde synthase *
EC 4.1.1.108: 4-hydroxyphenylacetaldehyde synthase *
EC 4.1.1.109: phenylacetaldehyde synthase *
EC 4.1.1.110: bisphosphomevalonate decarboxylase *
EC 4.1.1.111: siroheme decarboxylase *
EC 4.1.1.112: oxaloacetate decarboxylase *
EC 4.1.1.113: trans-aconitate decarboxylase *
EC 4.1.1.114: cis-3-alkyl-4-alkyloxetan-2-one decarboxylase *
EC 4.1.1.115: indoleacetate decarboxylase *
EC 4.1.1.116: D-ornithine/D-lysine decarboxylase *
EC 4.1.1.117: 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase *
EC 4.1.1.118: isophthalyl-CoA decarboxylase *
EC 4.1.1.119: phenylacetate decarboxylase *
EC 4.1.1.120: 3-oxoisoapionate decarboxylase *
EC 4.1.1.121: 3-oxoisoapionate-4-phosphate decarboxylase *

*No Wikipedia article

EC 4.1.2: Aldehyde-lyases

EC 4.1.2.1: Now included with EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
EC 4.1.2.2: ketotetrose-phosphate aldolase
EC 4.1.2.3: deleted, was pentosealdolase.
EC 4.1.2.4: deoxyribose-phosphate aldolase
EC 4.1.2.5: L-threonine aldolase
EC 4.1.2.6: Deleted, reaction is due to EC 2.1.2.1, glycine hydroxymethyltransferase
EC 4.1.2.7: Now included with EC 4.1.2.13 fructose-bisphosphate aldolase
EC 4.1.2.8: indole-3-glycerol-phosphate lyase
EC 4.1.2.9: phosphoketolase
EC 4.1.2.10: (R)-mandelonitrile lyase
EC 4.1.2.11: hydroxymandelonitrile lyase
EC 4.1.2.12: 2-dehydropantoate aldolase
EC 4.1.2.13: fructose-bisphosphate aldolase
EC 4.1.2.14: 2-dehydro-3-deoxy-phosphogluconate aldolase
EC 4.1.2.15: Now EC 2.5.1.54, 3-deoxy-7-phosphoheptulonate synthase
EC 4.1.2.16: Now EC 2.5.1.55, 3-deoxy-8-phosphooctulonate synthase
EC 4.1.2.17: L-fuculose-phosphate aldolase
EC 4.1.2.18: 2-dehydro-3-deoxy-L-pentonate aldolase
EC 4.1.2.19: rhamnulose-1-phosphate aldolase
EC 4.1.2.20: 2-dehydro-3-deoxyglucarate aldolase
EC 4.1.2.21: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
EC 4.1.2.22: fructose-6-phosphate phosphoketolase
EC 4.1.2.23: 3-deoxy-D-manno-octulosonate aldolase
EC 4.1.2.24: dimethylaniline-N-oxide aldolase
EC 4.1.2.25: dihydroneopterin aldolase
EC 4.1.2.26: phenylserine aldolase
EC 4.1.2.27: sphinganine-1-phosphate aldolase
EC 4.1.2.28: 2-dehydro-3-deoxy-D-pentonate aldolase
EC 4.1.2.29: 5-dehydro-2-deoxyphosphogluconate aldolase
EC 4.1.2.30: Now EC 1.14.14.32}, 17α-hydroxyprogesterone deacetylase
EC 4.1.2.31: Now included with EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
EC 4.1.2.32: trimethylamine-oxide aldolase
EC 4.1.2.33: fucosterol-epoxide lyase
EC 4.1.2.34: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
EC 4.1.2.35: propioin synthase
EC 4.1.2.36: lactate aldolase
EC 4.1.2.37: Now covered by EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)]
EC 4.1.2.38: benzoin aldolase
EC 4.1.2.39: Deleted, identical to EC 4.1.2.37, hydroxynitrilase
EC 4.1.2.40: tagatose-bisphosphate aldolase
EC 4.1.2.41: Now included with EC 4.1.2.61, feruloyl-CoA hydratase/lyase
EC 4.1.2.42: D-threonine aldolase
EC 4.1.2.43: 3-hexulose-6-phosphate synthase
EC 4.1.2.44: benzoyl-CoA-dihydrodiol lyase
EC 4.1.2.45: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
EC 4.1.2.46: aliphatic (R)-hydroxynitrile lyase
EC 4.1.2.47: (S)-hydroxynitrile lyase
EC 4.1.2.48: low-specificity L-threonine aldolase
EC 4.1.2.49: L-allo-threonine aldolase
EC 4.1.2.50: 6-carboxytetrahydropterin synthase
* EC 4.1.2.50: 6-carboxytetrahydropterin synthase *
* EC 4.1.2.51: 2-dehydro-3-deoxy-D-gluconate aldolase *
* EC 4.1.2.52: 4-hydroxy-2-oxoheptanedioate aldolase *
* EC 4.1.2.53: 2-keto-3-deoxy-L-rhamnonate aldolase *
* EC 4.1.2.54: L-threo-3-deoxy-hexylosonate aldolase *
* EC 4.1.2.55: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase *
* EC 4.1.2.56: 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase *
* EC 4.1.2.57: sulfofructosephosphate aldolase *
* EC 4.1.2.58: 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase *
* EC 4.1.2.59: dihydroneopterin phosphate aldolase *
* EC 4.1.2.60: dihydroneopterin triphosphate aldolase *
* EC 4.1.2.61: feruloyl-CoA hydratase/lyase *
* EC 4.1.2.62: 5-deoxyribulose 1-phosphate aldolase *
* EC 4.1.2.63: 2-hydroxyacyl-CoA lyase *

*No Wikipedia article

EC 4.1.3: Oxo-Acid-Lyases

EC 4.1.3.1: isocitrate lyase
EC 4.1.3.2: Now EC 2.3.3.9, malate synthase
EC 4.1.3.3: N-acetylneuraminate lyase
EC 4.1.3.4: hydroxymethylglutaryl-CoA lyase
EC 4.1.3.5: Now EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase
EC 4.1.3.6: citrate (pro-3S)-lyase
EC 4.1.3.7: Now EC 2.3.3.1, citrate (Si)-synthase
EC 4.1.3.8: Now EC 2.3.3.8, ATP citrate synthase
EC 4.1.3.9: Now EC 2.3.3.11, 2-hydroxyglutarate synthase
EC 4.1.3.10: Now EC 2.3.3.7, 3-ethylmalate synthase
EC 4.1.3.11: Now EC 2.3.3.12, 3-propylmalate synthase
EC 4.1.3.12: Now EC 2.3.3.13, 2-isopropylmalate synthase
EC 4.1.3.13: oxalomalate lyase
EC 4.1.3.14: L-erythro-3-hydroxyaspartate aldolase
EC 4.1.3.15: Now EC 2.2.1.5, 2-hydroxy-3-oxoadipate synthase
EC 4.1.3.16: 4-hydroxy-2-oxoglutarate aldolase
EC 4.1.3.17: 4-hydroxy-4-methyl-2-oxoglutarate aldolase
EC 4.1.3.18: Now EC 2.2.1.6, acetolactate synthase
EC 4.1.3.19: Now EC 2.5.1.56
EC 4.1.3.20: Now EC 2.5.1.57
EC 4.1.3.21: Now EC 2.3.3.14
EC 4.1.3.22: citramalate lyase
EC 4.1.3.23: Now EC 2.3.3.2, decylcitrate synthase
EC 4.1.3.24: malyl-CoA lyase
EC 4.1.3.25: (S)-citramalyl-CoA lyase
EC 4.1.3.26: 3-hydroxy-3-isohexenylglutaryl-CoA lyase
EC 4.1.3.27: anthranilate synthase
EC 4.1.3.28: Now EC 2.3.3.3, citrate (Re)-synthase
EC 4.1.3.29: Now EC 2.3.3.4, decylhomocitrate synthase
EC 4.1.3.30: methylisocitrate lyase
EC 4.1.3.31: Now EC 2.3.3.5, 2-methylcitrate synthase
EC 4.1.3.32: 2,3-dimethylmalate lyase
EC 4.1.3.33: Now EC 2.3.3.6
EC 4.1.3.34: citryl-CoA lyase
EC 4.1.3.35: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase
EC 4.1.3.36: naphthoate synthase
EC 4.1.3.37: Now EC 2.2.1.7, 1-deoxy-D-xylulose 5-phosphate synthase
EC 4.1.3.38: aminodeoxychorismate lyase
EC 4.1.3.39: 4-hydroxy-2-oxovalerate aldolase
EC 4.1.3.40: chorismate lyase
EC 4.1.3.41: 3-hydroxy-D-aspartate aldolase
EC 4.1.3.42: (4S)-4-hydroxy-2-oxoglutarate aldolase *
EC 4.1.3.43: 4-hydroxy-2-oxohexanoate aldolase *
EC 4.1.3.44: tRNA 4-demethylwyosine synthase (AdoMet-dependent) *
EC 4.1.3.45: 3-hydroxybenzoate synthase *
EC 4.1.3.46: (R)-citramalyl-CoA lyase *

*No Wikipedia article

EC 4.1.99: Other Carbon-Carbon Lyases

EC 4.1.99.1: tryptophanase
EC 4.1.99.2: tyrosine phenol-lyase
EC 4.1.99.3: deoxyribodipyrimidine photo-lyase
EC 4.1.99.4: Now EC 3.5.99.7, 1-aminocyclopropane-1-carboxylate deaminase
EC 4.1.99.5: octadecanal decarbonylase
EC 4.1.99.6: Now EC 4.2.3.6, trichodiene synthase
EC 4.1.99.7: Now EC 4.2.3.9, aristolochene synthase
EC 4.1.99.8: Now EC 4.2.3.14, pinene synthase
EC 4.1.99.9: Now EC 4.2.3.15, myrcene synthase
EC 4.1.99.10: Now EC 4.2.3.16, (4S)-limonene synthase
EC 4.1.99.11: benzylsuccinate synthase
EC 4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase
EC 4.1.99.13: (6-4)DNA photolyase
EC 4.1.99.14: spore photoproduct lyase
EC 4.1.99.15: The activity is covered by EC 4.1.99.14, spore photoproduct lyase
EC 4.1.99.16: geosmin synthase
EC 4.1.99.17: phosphomethylpyrimidine synthase
EC 4.1.99.18: Now known to be catalysed by the combined effect of EC 4.1.99.22, GTP 3,8-cyclase, and EC 4.6.1.17, cyclic pyranopterin monophosphate synthase
EC 4.1.99.19: 2-iminoacetate synthase
EC 4.1.99.20: 3-amino-4-hydroxybenzoate synthase *
EC 4.1.99.21: Now EC 4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase.
EC 4.1.99.22: GTP 3′,8-cyclase *
EC 4.1.99.23: 5-hydroxybenzimidazole synthase *
EC 4.1.99.24: L-tyrosine isonitrile synthase *
EC 4.1.99.25: L-tryptophan isonitrile synthase *
EC 4.1.99.26: 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one *

*No Wikipedia article

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

EC 4.2.1.1: carbonic anhydrase
EC 4.2.1.2: fumarate hydratase
EC 4.2.1.3: aconitate hydratase
EC 4.2.1.4: Now known to be a partial reaction catalysed by EC 4.2.1.3, aconitate hydratase
EC 4.2.1.5: arabinonate dehydratase
EC 4.2.1.6: galactonate dehydratase
EC 4.2.1.7: altronate dehydratase
EC 4.2.1.8: mannonate dehydratase
EC 4.2.1.9: dihydroxy-acid dehydratase
EC 4.2.1.10: 3-dehydroquinate dehydratase
EC 4.2.1.11: phosphopyruvate hydratase (enolase)
EC 4.2.1.12: phosphogluconate dehydratase
EC 4.2.1.13: Now EC 4.3.1.17, L-serine ammonia-lyase
EC 4.2.1.14: Now EC 4.3.1.18, D-serine ammonia-lyase
EC 4.2.1.15: Identical with EC 4.4.1.1 cystathionine γ-lyase
EC 4.2.1.16: Now EC 4.3.1.19, threonine ammonia-lyase
EC 4.2.1.17: enoyl-CoA hydratase
EC 4.2.1.18: methylglutaconyl-CoA hydratase
EC 4.2.1.19: imidazoleglycerol-phosphate dehydratase
EC 4.2.1.20: tryptophan synthase
EC 4.2.1.21: Now EC 4.2.1.22 cystathionine β-synthase
EC 4.2.1.22: cystathionine β-synthase
EC 4.2.1.23: deleted, the reaction was due to a side-reaction of EC 4.2.1.22 cystathionine β-synthase
EC 4.2.1.24: porphobilinogen synthase
EC 4.2.1.25: L-arabinonate dehydratase
EC 4.2.1.26: identical to EC 4.3.1.9, glucosaminate ammonia-lyase
EC 4.2.1.27: acetylenecarboxylate hydratase
EC 4.2.1.28: propanediol dehydratase
EC 4.2.1.29: Now EC 4.99.1.6, indoleacetaldoxime dehydratase
EC 4.2.1.30: glycerol dehydratase
EC 4.2.1.31: maleate hydratase
EC 4.2.1.32: L(+)-tartrate dehydratase
EC 4.2.1.33: 3-isopropylmalate dehydratase
EC 4.2.1.34: (S)-2-methylmalate dehydratase
EC 4.2.1.35: (R)-2-methylmalate dehydratase
EC 4.2.1.36: homoaconitate hydratase
EC 4.2.1.37: Now EC 3.3.2.4, trans-epoxysuccinate hydrolase
EC 4.2.1.38: Now EC 4.3.1.20, erythro-3-hydroxyaspartate ammonia-lyase
EC 4.2.1.39: gluconate dehydratase
EC 4.2.1.40: glucarate dehydratase
EC 4.2.1.41: 5-dehydro-4-deoxyglucarate dehydratase
EC 4.2.1.42: galactarate dehydratase
EC 4.2.1.43: 2-dehydro-3-deoxy-L-arabinonate dehydratase
EC 4.2.1.44: myo-inosose-2 dehydratase
EC 4.2.1.45: CDP-glucose 4,6-dehydratase
EC 4.2.1.46: dTDP-glucose 4,6-dehydratase
EC 4.2.1.47: GDP-mannose 4,6-dehydratase
EC 4.2.1.48: D-glutamate cyclase
EC 4.2.1.49: urocanate hydratase
EC 4.2.1.50: pyrazolylalanine synthase
EC 4.2.1.51: prephenate dehydratase
EC 4.2.1.52: Now EC 4.3.3.7, 4-hydroxy-2,3,4,5-tetrahydrodipicolinate synthase.
EC 4.2.1.53: oleate hydratase
EC 4.2.1.54: lactoyl-CoA dehydratase
EC 4.2.1.55: 3-hydroxybutyryl-CoA dehydratase
EC 4.2.1.56: itaconyl-CoA hydratase
EC 4.2.1.57: isohexenylglutaconyl-CoA hydratase
EC 4.2.1.58: The reaction described is covered by EC 4.2.1.59
EC 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
EC 4.2.1.60: 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
EC 4.2.1.61: The reaction described is covered by EC 4.2.1.59.
EC 4.2.1.62: 5α-hydroxysteroid dehydratase
EC 4.2.1.63: Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10)
EC 4.2.1.64: Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10)
EC 4.2.1.65: 3-cyanoalanine hydratase
EC 4.2.1.66: cyanide hydratase
EC 4.2.1.67: D-fuconate dehydratase
EC 4.2.1.68: L-fuconate dehydratase
EC 4.2.1.69: cyanamide hydratase
EC 4.2.1.70: pseudouridylate synthase
EC 4.2.1.71: identical to EC 4.2.1.27, acetylenecarboxylate hydratase
EC 4.2.1.72: Now EC 4.1.1.78, acetylenedicarboxylate decarboxylase
EC 4.2.1.73: protoaphin-aglucone dehydratase (cyclizing)
EC 4.2.1.74: long-chain-enoyl-CoA hydratase
EC 4.2.1.75: uroporphyrinogen-III synthase
EC 4.2.1.76: UDP-glucose 4,6-dehydratase
EC 4.2.1.77: trans-L-3-hydroxyproline dehydratase
EC 4.2.1.78: (S)-norcoclaurine synthase
EC 4.2.1.79: 2-methylcitrate dehydratase
EC 4.2.1.80: 2-oxopent-4-enoate hydratase
EC 4.2.1.81: D(-)-tartrate dehydratase
EC 4.2.1.82: xylonate dehydratase
EC 4.2.1.83: 4-oxalmesaconate hydratase
EC 4.2.1.84: nitrile hydratase
EC 4.2.1.85: dimethylmaleate hydratase
EC 4.2.1.86: identical to EC 4.2.1.98, 16α-hydroxyprogesterone dehydratase
EC 4.2.1.87: octopamine dehydratase
EC 4.2.1.88: synephrine dehydratase
EC 4.2.1.89: The activity has now been shown to be due to EC 2.8.3.21, L-carnitine CoA-transferase and EC 4.2.1.149, crotonobetainyl-CoA hydratase
EC 4.2.1.90: L-rhamnonate dehydratase
EC 4.2.1.91: arogenate dehydratase
EC 4.2.1.92: hydroperoxide dehydratase
EC 4.2.1.93: ATP-dependent NAD(P)H-hydrate dehydratase
EC 4.2.1.94: scytalone dehydratase
EC 4.2.1.95: kievitone hydratase
EC 4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase
EC 4.2.1.97: phaseollidin hydratase
EC 4.2.1.98: 16α-hydroxyprogesterone dehydratase
EC 4.2.1.99: 2-methylisocitrate dehydratase
EC 4.2.1.100: cyclohexa-1,5-dienecarbonyl-CoA hydratase
EC 4.2.1.101: Now included with EC 4.1.2.61, feruloyl-CoA hydratase/lyase
EC 4.2.1.102: Now EC 4.2.1.100, cyclohexa-1,5-dienecarbonyl-CoA hydratase
EC 4.2.1.103: cyclohexyl-isocyanide hydratase
EC 4.2.1.104: cyanase
EC 4.2.1.105: 2-hydroxyisoflavanone dehydratase
EC 4.2.1.106: bile-acid 7α-dehydratase
EC 4.2.1.107: 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase
EC 4.2.1.108: ectoine synthase
EC 4.2.1.109: methylthioribulose 1-phosphate dehydratase
EC 4.2.1.110: aldos-2-ulose dehydratase
EC 4.2.1.111: 1,5-anhydro-D-fructose dehydratase
EC 4.2.1.112: acetylene hydratase
EC 4.2.1.113: o-succinylbenzoate synthase
EC 4.2.1.114: methanogen homoaconitase
EC 4.2.1.115: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
EC 4.2.1.116: 3-hydroxypropionyl-CoA dehydratase
EC 4.2.1.117: 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
EC 4.2.1.118: 3-dehydroshikimate dehydratase
EC 4.2.1.119: enoyl-CoA hydratase 2
EC 4.2.1.120: 4-hydroxybutanoyl-CoA dehydratase
EC 4.2.1.121: colneleate synthase
EC 4.2.1.122: tryptophan synthase (indole-salvaging)
EC 4.2.1.123: tetrahymanol synthase
EC 4.2.1.124: arabidiol synthase
EC 4.2.1.125: dammarenediol II synthase
EC 4.2.1.126: N-acetylmuramic acid 6-phosphate etherase
EC 4.2.1.127: linalool dehydratase
EC 4.2.1.128: lupan-3β,20-diol synthase
EC 4.2.1.129: squalene—hopanol cyclase
EC 4.2.1.130: D-lactate dehydratase
EC 4.2.1.131: carotenoid 1,2-hydratase
EC 4.2.1.132: 2-hydroxyhexa-2,4-dienoate hydratase
EC 4.2.1.133: copal-8-ol diphosphate hydratase
EC 4.2.1.134: very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
EC 4.2.1.135: UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
EC 4.2.1.136: ADP-dependent NAD(P)H-hydrate dehydratase
EC 4.2.1.137: sporulenol synthase
EC 4.2.1.138: (+)-Caryolan-1-ol synthase
EC 4.2.1.139: pterocarpan synthase *
EC 4.2.1.140: gluconate/galactonate dehydratase *
EC 4.2.1.141: 2-dehydro-3-deoxyD-arabinonate dehydratase *
EC 4.2.1.142: 5′-oxoaverantin cyclase *
EC 4.2.1.143: versicolorin B synthase *
EC 4.2.1.144: 3-amino-5-hydroxybenzoate synthase *
EC 4.2.1.145: capreomycidine synthase *
EC 4.2.1.146: L-galactonate dehydratase *
EC 4.2.1.147: 5,6,7,8-tetrahydromethanopterin hydro-lyase *
EC 4.2.1.148: 2-methylfumaryl-CoA hydratase *
EC 4.2.1.149: crotonobetainyl-CoA hydratase *
EC 4.2.1.150: short-chain-enoyl-CoA hydratase *
EC 4.2.1.151: chorismate dehydratase *
EC 4.2.1.152: hydroperoxy icosatetraenoate dehydratase *
EC 4.2.1.153: 3-methylfumaryl-CoA hydratase *
EC 4.2.1.154: tetracenomycin F2 cyclase *
EC 4.2.1.155: (methylthio)acryloyl-CoA hydratase *
EC 4.2.1.156: L-talarate dehydratase *
EC 4.2.1.157: (R)-2-hydroxyisocaproyl-CoA dehydratase *
EC 4.2.1.158: galactarate dehydratase (D-threo-forming) *
EC 4.2.1.159: dTDP-4-dehydro-6-deoxy-α-glucopyranose 2,3-dehydratase *
EC 4.2.1.160: 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase *
EC 4.2.1.161: bisanhydrobacterioruberin hydratase *
EC 4.2.1.162: 6-deoxy-6-sulfo-D-gluconate dehydratase *
EC 4.2.1.163: 2-oxo-hept-4-ene-1,7-dioate hydratase *
EC 4.2.1.164: dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase *
EC 4.2.1.165: chlorophyllide a 3¹-hydratase *
EC 4.2.1.166: phosphinomethylmalate isomerase *
EC 4.2.1.167: (R)-2-hydroxyglutaryl-CoA dehydratase *
EC 4.2.1.168: GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase *
EC 4.2.1.169: 3-vinyl bacteriochlorophyllide d 3¹-hydratase *
EC 4.2.1.170: 2-(ω-methylthio)alkylmalate dehydratase *
EC 4.2.1.171: cis-L-3-hydroxyproline dehydratase *
EC 4.2.1.172: trans-4-hydroxy-L-proline dehydratase *
EC 4.2.1.173: ent-8α-hydroxylabd-13-en-15-yl diphosphate synthase *
EC 4.2.1.174: peregrinol diphosphate synthase *
EC 4.2.1.175: (R)-3-(aryl)lactoyl-CoA dehydratase *
EC 4.2.1.176: L-lyxonate dehydratase *
EC 4.2.1.177: (2S)-3-sulfopropanediol dehydratase *

*No Wikipedia article

EC 4.2.2: Acting on Polysaccharides

EC 4.2.2.1: hyaluronate lyase
EC 4.2.2.2: pectate lyase
EC 4.2.2.3: mannuronate-specific alginate lyase
EC 4.2.2.4: Now known to comprise two enzymes: EC 4.2.2.20, chondroitin-sulfate-ABC endolyase and EC 4.2.2.21, chondroitin-sulfate-ABC exolyase
EC 4.2.2.5: chondroitin AC lyase
EC 4.2.2.6: oligogalacturonide lyase
EC 4.2.2.7: heparin lyase
EC 4.2.2.8: heparin-sulfate lyase
EC 4.2.2.9: pectate disaccharide-lyase
EC 4.2.2.10: pectin lyase
EC 4.2.2.11: guluronate-specific alginate lyase
EC 4.2.2.12: xanthan lyase
EC 4.2.2.13: exo-(1→4)-α-D-glucan lyase
EC 4.2.2.14: glucuronan lyase
EC 4.2.2.15: anhydrosialidase
EC 4.2.2.16: levan fructotransferase (DFA-IV-forming)
EC 4.2.2.17: inulin fructotransferase (DFA-I-forming)
EC 4.2.2.18: inulin fructotransferase (DFA-III-forming)
EC 4.2.2.19: chondroitin B lyase
EC 4.2.2.20: chondroitin-sulfate-ABC endolyase
EC 4.2.2.21: chondroitin-sulfate-ABC exolyase
EC 4.2.2.22: pectate trisaccharide-lyase
EC 4.2.2.23: rhamnogalacturonan endolyase
EC 4.2.2.24: rhamnogalacturonan exolyase
EC 4.2.2.25: gellan lyase
EC 4.2.2.26: oligo-alginate lyase *
EC 4.2.2.27: pectin monosaccharide-lyase *

*No Wikipedia article

EC 4.2.3: Acting on phosphates

Enzymes from EC 4.2.3.141 on have no Wikipedia articles

EC 4.2.3.141: sclareol synthase
EC 4.2.3.142: 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC 4.2.3.143: kunzeaol synthase
EC 4.2.3.144: geranyllinalool synthase
EC 4.2.3.145: ophiobolin F synthase
EC 4.2.3.146: cyclooctat-9-en-7-ol synthase
EC 4.2.3.147: pimaradiene synthase
EC 4.2.3.148: cembrene C synthase
EC 4.2.3.149: nephthenol synthase
EC 4.2.3.150: cembrene A synthase
EC 4.2.3.151: pentamethylcyclopentadecatrienol synthase
EC 4.2.3.152: 2-epi-5-epi-valiolone synthase
EC 4.2.3.153: (5-formylfuran-3-yl)methyl phosphate synthase
EC 4.2.3.154: demethyl-4-deoxygadusol synthase
EC 4.2.3.155: 2-epi-valiolone synthase
EC 4.2.3.156: hydroxysqualene synthase
EC 4.2.3.157: (+)-isoafricanol synthase
EC 4.2.3.158: (–)-spiroviolene synthase
EC 4.2.3.159: tsukubadiene synthase
EC 4.2.3.160: (2S,3R,6S,9S)-(–)-protoillud-7-ene synthase
EC 4.2.3.161: (3S)-(+)-asterisca-2(9),6-diene synthase
EC 4.2.3.162: (–)-α-amorphene synthase
EC 4.2.3.163: (+)-corvol ether B synthase
EC 4.2.3.164: (+)-eremophilene synthase
EC 4.2.3.165: (1R,4R,5S)-(–)-guaia-6,10(14)-diene synthase
EC 4.2.3.166: (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
EC 4.2.3.167: dolabella-3,7-dien-18-ol synthase
EC 4.2.3.168: dolathalia-3,7,11-triene synthase
EC 4.2.3.169: 7-epi-α-eudesmol synthase
EC 4.2.3.170: 4-epi-cubebol synthase
EC 4.2.3.171: (+)-corvol ether A synthase
EC 4.2.3.172: 10-epi-juneol synthase
EC 4.2.3.173: τ-cadinol synthase
EC 4.2.3.174: (2E,6E)-hedycaryol synthase
EC 4.2.3.175: 10-epi-cubebol synthase
EC 4.2.3.176: sesterfisherol synthase
EC 4.2.3.177: β-thujene synthase
EC 4.2.3.178: stellata-2,6,19-triene synthase
EC 4.2.3.179: guaia-4,6-diene synthase
EC 4.2.3.180: pseudolaratriene synthase
EC 4.2.3.181: selina-4(15),7(11)-diene synthase
EC 4.2.3.182: pristinol synthase
EC 4.2.3.183: nezukol synthase
EC 4.2.3.184: 5-hydroxy-α-gurjunene synthase
EC 4.2.3.185: ent-atiserene synthase
EC 4.2.3.186: ent-13-epi-manoyl oxide synthase
EC 4.2.3.187: (2Z,6E)-hedycaryol synthase
EC 4.2.3.188: β-geranylfarnesene synthase
EC 4.2.3.189: 9,13-epoxylabd-14-ene synthase
EC 4.2.3.190: manoyl oxide synthase
EC 4.2.3.191: cycloaraneosene synthase
EC 4.2.3.192: labda-7,13(16),14-triene synthase
EC 4.2.3.193: (12E)-labda-8(17),12,14-triene synthase
EC 4.2.3.194: (–)-drimenol synthase
EC 4.2.3.195: rhizathalene A synthase
EC 4.2.3.196: dolabradiene synthase
EC 4.2.3.197: eudesmane-5,11-diol synthase
EC 4.2.3.198: α-selinene synthase
EC 4.2.3.199: (–)-5-epieremophilene synthase
EC 4.2.3.200: β-pinacene synthase
EC 4.2.3.201: hydropyrene synthase
EC 4.2.3.202: hydropyrenol synthase
EC 4.2.3.203: isoelisabethatriene synthase
EC 4.2.3.204: valerianol synthase
EC 4.2.3.205: sodorifen synthase

EC 4.2.99: Other Carbon-Oxygen Lyases

EC 4.2.99.1: Now EC 4.2.2.1, hyaluronate lyase
EC 4.2.99.2: Now EC 4.2.3.1, threonine synthase
EC 4.2.99.3: Now EC 4.2.2.2, pectate lyase
EC 4.2.99.4: Now EC 4.2.2.3, poly(β-D-mannuronate) lyase
EC 4.2.99.5: deleted
EC 4.2.99.6: Now included with EC 4.2.2.4 (chondroitin ABC lyase) and EC 4.2.2.5 (chondroitin AC lyase)
EC 4.2.99.7: Now EC 4.2.3.2, ethanolamine-phosphate phospho-lyase
EC 4.2.99.8: Now EC 2.5.1.47, cysteine synthase
EC 4.2.99.9: Now EC 2.5.1.48, cystathionine γ-synthase
EC 4.2.99.10: Now EC 2.5.1.49 EC 2.5.1.49, O-acetylhomoserine aminocarboxypropyltransferase
EC 4.2.99.11: Now EC 4.2.3.3, methylglyoxal synthase
EC 4.2.99.12: carboxymethyloxysuccinate lyase
EC 4.2.99.13: Now EC 2.5.1.50, zeatin 9-aminocarboxyethyltransferase
EC 4.2.99.14: Now EC 2.5.1.51, β-pyrazolylalanine synthase
EC 4.2.99.15: Now EC 2.5.1.52, L-mimosine synthase
EC 4.2.99.16: Now EC 2.5.1.53, uracilylalanine synthase
EC 4.2.99.17: Listed as EC 2.5.1.51, β-pyrazolylalanine synthase
EC 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase
EC 4.2.99.19: Now EC 4.4.1.23, 2-hydroxypropyl-CoM lyase
EC 4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
EC 4.2.99.21: isochorismate lyase
EC 4.2.99.22: tuliposide A-converting enzyme *
EC 4.2.99.23: tuliposide B-converting enzyme *
EC 4.2.99.24: thebaine synthase *

*No Wikipedia article

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

EC 4.3.1.1: aspartate ammonia-lyase
EC 4.3.1.2: methylaspartate ammonia-lyase
EC 4.3.1.3: histidine ammonia-lyase
EC 4.3.1.4: formiminotetrahydrofolate cyclodeaminase
EC 4.3.1.5: Now divided into EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase)
EC 4.3.1.6: β-alanyl-CoA ammonia-lyase
EC 4.3.1.7: ethanolamine ammonia-lyase
EC 4.3.1.8: Now EC 2.5.1.61, hydroxymethylbilane synthase
EC 4.3.1.9: glucosaminate ammonia-lyase
EC 4.3.1.10: serine-sulfate ammonia-lyase
EC 4.3.1.11: Deleted: inadequately characterized
EC 4.3.1.12: ornithine cyclodeaminase
EC 4.3.1.13: carbamoyl-serine ammonia-lyase
EC 4.3.1.14: 3-aminobutyryl-CoA ammonia-lyase
EC 4.3.1.15: diaminopropionate ammonia-lyase
EC 4.3.1.16: threo-3-hydroxy-L-aspartate ammonia-lyase
EC 4.3.1.17: L-serine ammonia-lyase
EC 4.3.1.18: D-serine ammonia-lyase
EC 4.3.1.19: threonine ammonia-lyase
EC 4.3.1.20: erythro-3-hydroxy-L-aspartate ammonia-lyase
EC 4.3.1.21: identical to EC 4.3.1.9, glucosaminate ammonia-lyase
EC 4.3.1.22: 3,4-dihydroxyphenylalanine reductive deaminase
EC 4.3.1.23: tyrosine ammonia-lyase
EC 4.3.1.24: phenylalanine ammonia-lyase
EC 4.3.1.25: phenylalanine/tyrosine ammonia-lyase
EC 4.3.1.26: Now EC 1.21.3.9, dichlorochromopyrrolate synthase
EC 4.3.1.27: threo-3-hydroxy-D-aspartate ammonia-lyase
EC 4.3.1.28: L-lysine cyclodeaminase
EC 4.3.1.29: D-glucosaminate-6-phosphate ammonia-lyase *
EC 4.3.1.30: dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase *
EC 4.3.1.31: L-tryptophan ammonia lyase *
EC 4.3.1.32: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase *

*No Wikipedia article

EC 4.3.2: Amidine-Lyases

EC 4.3.2.1: argininosuccinate lyase
EC 4.3.2.2: adenylosuccinate lyase
EC 4.3.2.3: ureidoglycolate lyase
EC 4.3.2.4: purine imidazole-ring cyclase
EC 4.3.2.5: peptidylamidoglycolate lyase
EC 4.3.2.6: γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase
EC 4.3.2.7: glutathione-specific γ-glutamylcyclotransferase *
EC 4.3.2.8: γ-glutamylamine cyclotransferase *
EC 4.3.2.9: γ-glutamylcyclotransferase *
EC 4.3.2.10: imidazole glycerol-phosphate synthase *

*No Wikipedia article

EC 4.3.3: Amine-Lyases

EC 4.3.99: Other Carbon-Nitrogen Lyases

EC 4.3.99.1: Now EC 4.2.1.104, cyanate hydratase
EC 4.3.99.2: Now EC 7.2.4.1, carboxybiotin decarboxylase
EC 4.3.99.3: 7-carboxy-7-deazaguanine synthase
EC 4.3.99.4: choline trimethylamine-lyase *

*No Wikipedia article

EC 4.4: Carbon-Sulfur Lyases

EC 4.4.1: Carbon-sulfur lyases (only sub-subclass identified to date)

EC 4.4.1.1: cystathionine γ-lyase
EC 4.4.1.2: homocysteine desulfhydrase
EC 4.4.1.3: dimethylpropiothetin dethiomethylase
EC 4.4.1.4: alliin lyase
EC 4.4.1.5: lactoylglutathione lyase
EC 4.4.1.6: Now included in EC 4.4.1.13, cysteine-S-conjugate β-lyase
EC 4.4.1.7: Now included with EC 2.5.1.18 glutathione transferase
EC 4.4.1.8: Now included in EC 4.4.1.13, cysteine-S-conjugate β-lyase
EC 4.4.1.9: L-3-cyanoalanine synthase
EC 4.4.1.10: cysteine lyase
EC 4.4.1.11: methionine γ-lyase
EC 4.4.1.12: deleted: activity due to EC 2.3.3.15, sulfoacetaldehyde acetyltransferase
EC 4.4.1.13: cysteine-S-conjugate β-lyase
EC 4.4.1.14: 1-aminocyclopropane-1-carboxylate synthase
EC 4.4.1.15: D-cysteine desulfhydrase
EC 4.4.1.16: selenocysteine lyase
EC 4.4.1.17: holocytochrome-c synthase
EC 4.4.1.18: Now EC 1.8.3.5, prenylcysteine oxidase
EC 4.4.1.19: phosphosulfolactate synthase
EC 4.4.1.20: leukotriene-C₄ synthase
EC 4.4.1.21: S-ribosylhomocysteine lyase
EC 4.4.1.22: S-(hydroxymethyl)glutathione synthase
EC 4.4.1.23: 2-hydroxypropyl-CoM lyase
EC 4.4.1.24: (2R)-sulfolactate sulfo-lyase
EC 4.4.1.25: L-cysteate sulfo-lyase
EC 4.4.1.26: olivetolic acid cyclase
EC 4.4.1.27: Now EC 3.13.1.5, carbon disulfide hydrolase

*No Wikipedia article

EC 4.5: Carbon-Halide Lyases

EC 4.5.1: Carbon-halide lyases (only sub-subclass identified to date)

EC 4.6: Phosphorus-Oxygen Lyases

EC 4.6.1: Phosphorus-oxygen lyases (only sub-subclass identified to date)

EC 4.6.1.1: adenylate cyclase
EC 4.6.1.2: guanylate cyclase
EC 4.6.1.3: Now EC 4.2.3.4, 3-dehydroquinate synthase
EC 4.6.1.4: Now EC 4.2.3.5, chorismate synthase
EC 4.6.1.5: Now EC 4.2.3.7, pentalenene synthase
EC 4.6.1.6: cytidylate cyclase
EC 4.6.1.7: Now EC 4.2.3.8, casbene synthase
EC 4.6.1.8: Now EC 4.2.3.10, (-)-endo-fenchol synthase
EC 4.6.1.9: Now Now EC 4.2.3.11, sabinene-hydrate synthase
EC 4.6.1.10: Now EC 4.2.3.12, 6-pyruvoyltetrahydropterin synthase
EC 4.6.1.11: Now EC 4.2.3.13, (+)-δ-cadinene synthase
EC 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
EC 4.6.1.13: phosphatidylinositol diacylglycerol-lyase
EC 4.6.1.14: glycosylphosphatidylinositol diacylglycerol-lyase
EC 4.6.1.15: FAD-AMP lyase (cyclizing)
EC 4.6.1.16: tRNA-intron lyase
EC 4.6.1.17: cyclic pyranopterin monophosphate synthase *
EC 4.6.1.18: pancreatic ribonuclease *
EC 4.6.1.19: ribonuclease T₂ *
EC 4.6.1.20: ribonuclease U₂ *
EC 4.6.1.21: Enterobacter ribonuclease *
EC 4.6.1.22: Bacillus subtilis ribonuclease *
EC 4.6.1.23: ribotoxin *
EC 4.6.1.24: ribonuclease T₁ *
EC 4.6.1.25: bacteriophage T₄ restriction endoribonuclease RegB *

*No Wikipedia article

EC 4.7: Carbon-phosphorus lyases

EC 4.7.1: Carbon-phosphorus lyases (only sub-subclass identified to date)

EC 4.7.1.1 α-D ribose 1-methylphosphonate 5-phosphate C-P-lyase *

*No Wikipedia article

EC 4.8: Nitrogen-oxygen lyases

EC 4.8.1: Hydro-lyases

EC 4.8.1.1: L-piperazate synthase *
EC 4.8.1.2: aliphatic aldoxime dehydratase *
EC 4.8.1.3: indoleacetaldoxime dehydratase *
EC 4.8.1.4: phenylacetaldoxime dehydratase *

*No Wikipedia article

EC 4.98: ATP-independent chelatases

EC 4.98.1: Forming coordination complexes

EC 4.98.1.1: protoporphyrin ferrochelatase

EC 4.99: Other Lyases

EC 4.99.1: Sole sub-subclass for lyases that do not belong in the other subclasses

EC 4.99.1.1: Now EC 4.98.1.1
EC 4.99.1.2: alkylmercury lyase
EC 4.99.1.3: sirohydrochlorin cobaltochelatase
EC 4.99.1.4: sirohydrochlorin ferrochelatase
EC 4.99.1.5: Now EC 4.8.1.2, aliphatic aldoxime dehydratase
EC 4.99.1.6: Now EC 4.8.1.3, indoleacetaldoxime dehydratase
EC 4.99.1.7: Now EC 4.8.1.4, phenylacetaldoxime dehydratase
EC 4.99.1.8: heme ligase
EC 4.99.1.9:: coproporphyrin ferrochelatase *
EC 4.99.1.10: magnesium dechelatase *
EC 4.99.1.11: sirohydrochlorin nickelchelatase *
EC 4.99.1.12: pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase *

*No Wikipedia article

References

^ "ExplorEnz – The Enzyme Database".
^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37: D593–D597. doi:10.1093/nar/gkn582. PMC 2686581.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

v t e Carbon–carbon lyases (EC 4.1)
4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Arginine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase
4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase
4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase
4.1.99: Other	Tryptophanase Photolyase CPD lyase Spore photoproduct lyase

v t e Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)
4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase
4.2.2: Acting on polysaccharides	Hyaluronate lyase Pectin lyase
4.2.3: Acting on phosphates	Threonine synthase
4.2.99: Other	Carboxymethyloxysuccinate lyase Hydroperoxide lyase

v t e Carbon–nitrogen lyases (EC 4.3)
4.3.1: ammonia-lyases	Histidine ammonia-lyase Formiminotransferase cyclodeaminase Serine dehydratase Phenylalanine ammonia-lyase
4.3.2: amidine-lyases	Argininosuccinate lyase Adenylosuccinate lyase

Phosphorus–oxygen lyases (EC 4.6)

4.6.1

Adenylate cyclase
(4.6.1.1)

intracellular	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY10
extracellular	Extracellular adenylate cyclase

Guanylate cyclase
(4.6.1.2)

soluble guanylyl cyclase	GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3
guanylate cyclase-coupled receptor	GUCY2C GUCY2D ANP (NPR1 NPR2)

Other