Identifiers | |
---|---|
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C18H19NO |
Molar mass | 265.356 g·mol−1 |
3D model (JSmol) | |
| |
|
HP-505 is a triple reuptake inhibitor that was investigated by Hoechst-Roussel Pharmaceuticals.[1] In mice, HP-505 was a potent inhibitor of tetrabenazine-induced ptosis which may indicate antidepressant activity.[2]
5-HT | NE | DA | NE:5-HT | DA:5-HT |
---|---|---|---|---|
0.19 ± 0.04 | 0.34 ± 0.1 | 0.66 ± 0.15 | 1.8 | 3.5 |
The inhibitory effect of HP-505 on serotonin reuptake is approximately 1.8 and 3.5 times stronger than on norepinephrine and dopamine, respectively.[1] Subsequent investigations have found that HP-505 acts on presynaptic dopamine transporters and is devoid of anticholinergic effects.[3]
The N-methylated analog is called HP-365 [59142-29-9].
An older synthesis is available, although more modern methods exist now:[4]