This article is missing information about structure (universal). Please expand the article to include this information. Further details may exist on the talk page. (December 2020)

Large subunit ribosomal ribonucleic acid (LSU rRNA) is the largest of the two major RNA components of the ribosome. Associated with a number of ribosomal proteins, the LSU rRNA forms the large subunit of the ribosome. The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation.

Other data
PDB structuresPDBe


Characteristics of the LSU rRNA for exemplary species.
Type LSU rRNA size Species Length Accession Reference
Bacterial (Prokaryotic) 23S Escherichia coli 2,905 nt NR_076322.1 [1]
Archaeal (Prokaryotic) 23S Halobacterium salinarum 2,906 nt NR_076247.1 [2]
Eukaryotic 5.8S & 28S Homo sapiens 157 + 5,025 nt NR_145821.1; M11167.1 [3][4]
Mitochondrial 16S Homo sapiens 1,559 nt NC_012920.1 [5][6]
Plastid 23S Arabidopsis thaliana 2,810 nt NC_000932.1 [7]

Use in phylogenetics

LSU rRNA sequences are widely used for working out evolutionary relationships among organisms, since they are of ancient origin and are found in all known forms of life.

See also


  1. ^ "Escherichia coli 23S ribosomal RNA". 3 February 2015.
  2. ^ "Halobacterium salinarum 23S ribosomal RNA". 3 February 2015.
  3. ^ "Homo sapiens RNA, 5.8S ribosomal N1 (RNA5-8SN1), ribosomal RNA". 3 July 2020.
  4. ^ "Homo sapiens 28S ribosomal RNA (nuclear)". 10 November 1986.
  5. ^ Homo sapiens mitochondrion, complete genome. "Revised Cambridge Reference Sequence (rCRS): accession NC_012920", National Center for Biotechnology Information. Retrieved on 20 February 2017.
  6. ^ Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome". Nature. 290 (5806): 457–465. Bibcode:1981Natur.290..457A. doi:10.1038/290457a0. PMID 7219534.
  7. ^ "Arabidopsis thaliana 23S ribosomal RNA (chloroplast)". 3 April 2023.