Protein-coding gene in the species Homo sapiens
Major vault protein (MVP), also known as lung resistance-related protein (LRP) is a protein that in humans is encoded by the MVP gene.[5][6] 78 copies of the protein assemble into the large compartments called vaults.
Function
This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[6]
Major vault protein coimmunoprecipitates with the human estrogen receptor and treatment with estradiol increases MVP associated with the estrogen receptor in nuclear extracts.[7]
Interactions
Major vault protein has been shown to interact with Estrogen receptor alpha,[8] PTEN[9] and PARP4.[10][11]