Millersburg is one of the oldest settlements in Callaway County to be established after Missouri statehood in 1821, and was located along the southernmost historic "Boone's Lick" trail route of about 1826.[3] Millersburg was platted in 1829.[4] The community derives its name from Thomas Miller, a pioneer settler from Kentucky.[5] A local post office called Millersburg was established in 1830, and remained in operation until 1953.[6]
^Bell, Ovid. "A Short History of Callaway County" published in "A History of Northeast Missouri", Walter Williams, Ed. Chicago: Lewis Publishing Co.,1913. [1]