Nyssa is an unincorporated community in southeast Butler County, in the U.S. state of Missouri.[1]
The community is on Missouri Route 51 2.5 miles south of Broseley and three miles north of Qulin. Poplar Bluff is eleven miles to the northwest.[2]
The community was a timber station on the old Chicago, Burlington and Quincy Railroad. Nyssa is the generic botanical name for the locally abundant tupelo gum. William N. Barron gave the town its name.[3]