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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.237.268 |
Chemical and physical data | |
Formula | C21H17Cl3N4OS |
Molar mass | 479.80 g·mol−1 |
3D model (JSmol) | |
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Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes[1][2][3] and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit,[4] resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum.[5] Salubrinal has putative therapeutic value due to its function,[1][3] but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.[6]