Thanks Arcadian for all your hard work in extending the ((transcription coregulators)) NavBox, but unfortunately it appears that only TRIM24, TRIM28, TRIM33, and TRIM65 tripartite motif family members act as corepressors. What these four members share in common is a PHD-BROMO domain which none of the other members of the TRIM family possess. The PHD-BROMO domain is also found in several other coregulators such as p300/CBP and is necessary for binding to the nucleosome and this interaction appears crucial to coregulatory action of these proteins. I hope you don't mind, but I propose to undo the expansion. Cheers. Boghog2 (talk) 19:52, 22 February 2009 (UTC)Reply[reply]

Thanks for catching that, and sorry for my error. --Arcadian (talk) 21:34, 22 February 2009 (UTC)Reply[reply]

No problem and thanks for your response. I wasn't sure myself until I read a few background articles. The function and mechanism of most of the TRIM family members remains somewhat unclear. Many could be transcription factors but as far as I can tell, this has not been demonstrated yet. Boghog2 (talk) 22:17, 22 February 2009 (UTC)Reply[reply]