Upalika is an extinct town in southwest Wayne County, in the U.S. state of Missouri. The GNIS classifies it as a populated place.[1] The community is on County Road 426 five miles southwest of Williamsville and 5.5 miles east of Ellsinore in adjacent Carter County.[2]
Upalika had its start ca. 1891 when the railroad was extended to that point.[3] A post office called Upalika was established in 1892, and remained in operation until 1927.[4] Some maintain the name "Upalika" is Native American in origin, while others believe a railroad worker gave the community the name of his wife.[3]