Uppaluri is a Telugu surname originating from Gudivada in the Krishna district of Andhra Pradesh of India.^{[citation needed]} They mostly belong to the class of Brahmins. Alternative spellings of this surname include Uppuluri, Vuppuluri and Vuppulury.

Notable people with the surname include:

• Subbaraya Sarma (born Uppaluri Subbaraya Sarma, 1947), Indian actor
• U. G. Krishnamurti (1918–2007), Indian philosopher
• Uppuluri Mallikarjuna Sarma (1939–2019), Indian politician
• U. S. R. Murty, Indian mathematician and professor
• Vuppuluri Ganapathi Sastry (1888–1989), Indian Sanskrit scholar, writer and spiritual teacher