Yizhi or Yi Zhi may refer to:

Places

Yizhi Township (simplified Chinese: 益智乡; traditional Chinese: 益智鄉; pinyin: Yìzhì-zhèn), Jinggu, Yi, Yunnan, China

People

Yi Zhi (♂, circa 17th-century BCE; pinyin: Yī Zhì), a Shang dynasty Chinese politician

Yan Yuan (Qing dynasty) (♂, 1635–1704, known as "Yizhi"), Qing dynasty Chinese philosopher
Yizhi (prince) (♂, 1827–1850; Chinese: 瑞敏郡王奕志; pinyin: Ruìmǐn-jùn Wáng Yìzhì; lit. 'Wang Yizhi of Ruimin County'), Qing dynasty imperial prince

Dexmon Chua Yizhi (♂, 1976–2013; Chinese: 蔡谊志; pinyin: Caì Yìzhì, also Dexmon Chua), Singaporean materials analyst and murder victim
Cheng Yizhi (♀, 1902–1997; Chinese: 程毅志), Chinese politician
Dou Yizhi (♂, died 833 CE; Chinese: 竇易直), Tang dynasty Chinese politician
Juzhi Yizhi (♂, 9th-century CE; Chinese: 俱胝一指; pinyin: Jùzhī Yīzhǐ; Japanese pronunciation: Gutei Isshi), Chinese Buddhist Chan/Zen Master
Li Yizhi (♀, born 1977), Chinese volleyball player
Liu Yizhi (♂, 631–687; Chinese: 劉禕之), Tang dynasty Chinese politician
Qin Yizhi (♂, born 1965; Chinese: 秦宜智), Chinese politician
Yizhi Jane Tao, Chinese biochemist
Zhang Yizhi (♂, died 705 CE; Chinese: 張易之), Duke of Heng; Zhou dynasty Chinese politician

Yizhi (Chinese: 儀質), a wuxia character from The Smiling, Proud Wanderer by Jin Yong
Ping Yizhi (Chinese: 平一指), a wuxia character from The Smiling, Proud Wanderer by Jin Yong
Yizhi Nishidu (Chinese: 伊質泥師都), a legendary character, ancestor of all Turkic peoples, including the Ashina Tuwu