Cave: notitiae huius paginae nec praescriptiones nec consilia medica sunt.

Bisoprololum est substantia chemica beta-receptoria typi primi inhibens et propterea medicamentum antihypertensivum velut antiarrhythmicum classis II est.

Bisoprololum in ordinis mundi sanitarii indicem exemplarem medicamentorum essentialium receptum est.

Natura Bisoprololi

Natura chemica

Bisoprololum beta1-receptoria valde selective inhibet.

Bisoprololum est beta1-receptoriorum inhibitor. Structura eius chemica est (RS)-1-[4-(2-isopropoxyethoxymethyl)phenoxy]-3-isopropylamino-2-propanolum.

Formula chemica est C18H31NO4, massa molaris 325.45 g/mol. Codex ATC est C07AB07 (WHO).

Natura pharmacologica

Pharmacocinetica

Solubilitas in aqua est 2.24 g·mol−1 (25 °C), accessibilitas biologica 90%. Tempus semivitae biologicum .[1]10 – 12 h est.

Bisoprololum substratum et Cytochromatis P450 CYP2D6 ( (R)-(+)-bisoprololum > (S)-(-)-bisoprololum ) et CYP3A4 ( (R)=(S) ) est.[2]

Interactiones

Cum Bisoprololum subtratum enzymi CYP3A4 esset, inhibitores CYP3A4 effectus Bisoprololi augere possint, inductores invicem diminuere, per exemplum:

Pharmaca cum effectibus Bisoprololi substrati
Inhibitores cum Bisoprololi effectibus fortioribus Inductores cum Bisoprololi effectibus minoribus
  • Antihypertensiva
  • Antiarrhythmica
    • Amiodaronum
    • Dronedaronum
  • Antidepressiva
    • Fluvoxaminum
    • Nefazodonum (forte)
  • Diuretica/Hormonta
    • Conivaptanum (forte)
  • Antibiotica
    • Ciprofloxacinum
    • Macrolida
      • Clarithromycinum (forte)
      • Erythromycinum (forte)
      • Telithromycinum (forte)
  • Antiemetica
    • Aprepitantum
  • Fungicida/-statica
    • Fluconazolum
    • Ketoconazolum (forte)
    • Isavuconazolum
    • Itraconazolum (forte)
    • Posaconazolum (forte)
    • Voriconazolum (forte)
  • Proteasis inhibitores
    • Atazanavirum-Ritonavirum
    • Boceprevirum (forte)
    • Cobicistatum (forte)
    • Indinavirum (forte)
    • Lopinavirum cum Ritonaviro (forte)
    • Nelfinavirum (forte)
    • Ritonavirum (forte)
    • Saquinavirum (forte)
    • Telaprevirum (forte)
  • Idelalisibum (forte)
  • Imatinibum
  • Nilotinibum
  • Ribociblibum (forte)
  • Glucocorticoides
    • Dexamethasonum (forte)
  • Verapamilum
  • Hormonta
    • GH
  • Plantae
  • Anticonvulsiva
    • Carbamazepinum (forte, quoque P-gp)
    • Phenytoinum (forte)
    • Fosphenytoinum (forte)
    • Oxcarbazepinum (forte)
    • Eslicarbazepinacetatum
    • Topiramatum
    • Phenobarbitalum (forte)
    • Primidonum (forte)
  • Antidepressiva
    • Hypericum perforatum (forte, quoque P-gp)
  • Antihypertensiva
    • Bosentanum (forte, endothelini receptoris inhibitor)
  • Substantiae antiretrovirales
    • Efavirenzum (forte)
    • Etravirinum (forte)
    • Nevirapinum (forte)
  • Substantiae antineoplasticae
    • Dabrafenibum
    • Enzalutamidum
    • Mitotanum (forte)
  • Antibiotica
    • Rifabutinum (forte)
    • Rifapentinum (forte)
    • Nafcillinum (forte)
    • Rifampicinum (forte)
  • Hormonta
    • Triiodthyroninum (T3)
  • Antiandrogena
    • Apalutamidum
  • Modafinilum
  • Quercetinum
  • Capsaicinum

Notae

  1. ↑ http://goldbook.iupac.org/B00658.html
  2. ↑ Yuji Horikiri; Takehiko Suzuki; Masakazu Mizobe (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences 87 (3): 289–294 

Nexus interni

Categoriae