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Duloxetinum
Cognitores
ChemSpider 54822
PubChem 60835
DrugBank DB00476
Natura chemica
Duloxetinum
Duloxetinum
Formula chemica C
18H
19NOS
Massa molaris 297.42 g/mol
Natura pharmacologica
Codex ATC N06AX21 (WHO)
Semivita biologica 12 h
Metabolismus iecore (hepaticus):
CYP1A2, CYP2D6
Excretio renibus (70%), faecibus (20%)
Ad usum therapeuticum
Applicatio per os

Duloxetinum est antidepressivum et inhibitor reabsorptionis serotonini noradrenalinique[1].

Pharmacocinetica

Semivita biologica .[2] 12 h est. Duloxetinum substratum cytochromatum CYP1A2 et CYP2D6 est. Excretio est maiore in parte per renes (70%), minore per faeces (20%).

Notae

  1. ↑ Wong D. T., Bymaster F. P. (2002). "Dual serotonin and noradrenaline uptake inhibitor class of antidepressants potential for greater efficacy or just hype?". Progress in drug research 58: 169-22 
  2. ↑ http://goldbook.iupac.org/B00658.html

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