Formil peptidni receptor 3

Identifikatori

FPR3; FPRL2; FMLPY; RMLP-R-I

Vanjski ID

OMIM: 136539 MGI: 1194495 HomoloGene: 40605 IUPHAR: FPR3 GeneCards: FPR3 Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora • receptorska aktivnost • aktivnost N-formil peptidnog receptora
Celularna komponenta	• ćelijska membrana • integralno sa membranom
Biološki proces	• ćelijska motilnost • hemotaksa • prenos signala • signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 19:
56.99 - 57.02 Mb

Chr 17:
18.02 - 18.11 Mb

PubMed pretraga

[1]

[2]

N-formil peptidni receptor 3 je protein koji je kod ljudi kodiran FPR3 genom.^[1]^[2]^[3]

Vidi još

Formil peptidni receptor

Literatura

^ Bao L, Gerard NP, Eddy RL Jr, Shows TB, Gerard C (1992). „Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19”. Genomics. 13 (2): 437—40. PMID 1612600. doi:10.1016/0888-7543(92)90265-T.
^ Durstin M, Gao JL, Tiffany HL, McDermott D, Murphy PM (1994). „Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes”. Biochem Biophys Res Commun. 201 (1): 174—9. PMID 8198572. doi:10.1006/bbrc.1994.1685.
^ „Entrez Gene: FPRL2 formyl peptide receptor-like 2”.

Dodatna literatura

Christophe T; Karlsson A; Dugave C; et al. (2001). „The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.”. J. Biol. Chem. 276 (24): 21585—93. PMID 11285256. doi:10.1074/jbc.M007769200.
Yang D; Chen Q; Gertz B; et al. (2002). „Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.”. J. Leukoc. Biol. 72 (3): 598—607. PMID 12223529.
Christophe T; Karlsson A; Rabiet MJ; et al. (2002). „Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.”. Scand. J. Immunol. 56 (5): 470—6. PMID 12410796. doi:10.1046/j.1365-3083.2002.01149.x.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Ernst S; Lange C; Wilbers A; et al. (2004). „An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.”. J. Immunol. 172 (12): 7669—76. PMID 15187149.
Harada M; Habata Y; Hosoya M; et al. (2004). „N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.”. Biochem. Biophys. Res. Commun. 324 (1): 255—61. PMID 15465011. doi:10.1016/j.bbrc.2004.09.046.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kang HK; Lee HY; Kim MK; et al. (2005). „The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.”. J. Immunol. 175 (2): 685—92. PMID 16002663.
Lee HY; Lee SY; Shin EH; et al. (2007). „F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling.”. Biochem. Biophys. Res. Commun. 359 (4): 985—90. PMID 17577578. doi:10.1016/j.bbrc.2007.06.001.

Spoljašnje veze

„Formylpeptide Receptors: FPRL2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 18. 05. 2015. г.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

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