In Greek mythology, Epione (Ancient Greek: Ἠπιόνη) is married to Asclepius.^[1] Her name is derived from the word ἤπιος (epios, "soothing"). Epione was the personification of the soothing of pain and the care needed for recovery.^[1] With Asclepius, she was the mother of the five Asclepiades: Aceso, Aglaea, Hygieia, Iaso, Achelois and Panacaea, as listed in the Suda.^[2] She also had two sons, Machaon and Podalirius, who are mentioned in the Iliad of Homer^[3] as well as Telesphoros.^[4]

Epigraphical evidence suggests that Epione was a cultic figure in Athens, Epidauros, Kos, and Pergamon.^[1] Asclepius and Epione both had marble statues in Argolis, where Asclepius was widely worshipped.