Teams of scientists/engineers
- A team of scientists who investigate a deadly disease in The Andromeda Strain
- Arcot, Wade and Morey – scientist-inventors in science fiction stories by John W. Campbell
- The Baltimore Gun Club in From the Earth to the Moon – three of its wealthy members (Victor Barbicane, Stuyvesant Nicholl, Ben Sharpe) build a giant gun which launches an occupied capsule to the Moon
- Bunsen and Beaker in The Muppets
- Challengers of the Unknown – four scientific explorers
- Eureka (Eureka) - a hidden-away town in Oregon where everyone, even the young children, are scientific geniuses.
- Forensic scientists who use their skills to solve crimes in CSI: Crime Scene Investigation, CSI: NY and CSI: Miami
- Edward Elric and Alphonse Elric – alchemist brothers who seek the legendary Philosopher's stone, and end up saving their country with their alchemical skills
- Ghostbusters – most of the central characters (Peter Venkman, Raymond Stantz, Egon Spengler and Winston Zeddemore) are parapsychologists who battle ghosts and other supernatural menaces with equipment of their own design
- Global Dynamics (Eureka) - a major research facility in the town of Eureka, where most of America's top-secret government experiments are conducted.
- The Kihara family of mad scientists are dedicated to the pursuit of science whatever the cost, in A Certain Magical Index; individual members are often antagonists
- The Last Three of Venus – Venusian scientists, adversaries of Dan Dare
- The League of Extraordinary Gentlemen
- The Lone Gunmen – ardent conspiracy theorists and computer hackers who frequently assist central X-Files characters Mulder and Scully, though they sometimes have their own adventures
- LOVEMUFFIN (League of Villainous Evildoers Maniacally United For Frightening Investments in Naughtiness) – group of evil mad scientists in Phineas and Ferb, including Dr Heinz Doofenshmirtz
- STUDY – group of frustrated young adult scientists acting as antagonists in A Certain Scientific Railgun S
- The Speedwagon Foundation – group consisting of doctors and archaeologists founded by Robert E. O. Speedwagon somewhere between the story arcs of Phantom Blood and Battle Tendency in JoJo's Bizarre Adventure; extremely knowledgeable on Stands, Pillar Men and Dio
- Unorthodox Engineers – misfit bunch of engineers who solve problems of alien technology/weird planets in the future
- The K-science team: Hong Kong Shatterdome (Newton Geiszler and Hermann Gottlieb) – heads of the kaiju science research team (Pacific Rim)
