Bipolar disorder
SpecialtyPsychiatry Edit this on Wikidata
Symptomsmood instability, psychosis in some cases
Usual onset25 years of age
Differential diagnosisOther bipolar disorders, borderline personality disorder, antisocial personality disorder
TreatmentTherapy, mood stabilizing medication such as lithium
MedicationLithium, anticonvulsants, antipsychotics
Deaths6% die by suicide

Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features.[1] Most people also, at other times, have one or more depressive episodes.[2] Typically, these manic episodes can last at least 7 days for most of each day to the extent that the individual may need medical attention. Also, the depressive episodes will be approximately 2 weeks long.[3]

It is a type of bipolar disorder and conforms to the classic concept of manic-depressive illness, which can include psychosis during mood episodes.[4]


The essential feature of bipolar I disorder is a clinical course characterized by the occurrence of one or more manic episodes or mixed episodes.[5] Often, individuals have had one or more major depressive episodes.[6] One episode of mania is sufficient to make the diagnosis of bipolar disorder; the person may or may not have a history of major depressive disorder.[6] Episodes of substance-induced mood disorder due to the direct effects of a medication, or other somatic treatments for depression, substance use disorder, or toxin exposure, or of mood disorder due to a general medical condition need to be excluded before a diagnosis of bipolar I disorder can be made. Bipolar I disorder requires confirmation of only 1 full manic episode for diagnosis, but may be associated with hypomanic and depressive episodes as well.[7] Diagnosis for bipolar II disorder does not include a full manic episode; instead, it requires the occurrence of both a hypomanic episode and a major depressive episode.[7] Serious aggression has been reported to occur in one out of every ten major, first-episode, BD-I patients with psychotic features, the prevalence in this group being particularly high in association with a recent suicide attempt, alcohol use disorder, learning disability, or manic polarity in the first episode.[8]

Bipolar I disorder often coexists with other disorders including PTSD, substance use disorders, and a variety of mood disorders.[9][10] Studies suggest that psychiatric comorbidities correlate with further impairment of day-to-day life.[11] Up to 40% of people with bipolar disorder also present with PTSD, with higher rates occurring in women and individuals with bipolar I disorder.[9] A diagnosis of bipolar 1 disorder is only given if bipolar episodes are not better accounted for by schizoaffective disorder or superimposed on schizophrenia, schizophreniform disorder, delusional disorder, or a psychotic disorder not otherwise specified.[12]

Medical assessment

Regular medical assessments are performed to rule-out secondary causes of mania and depression.[13] These tests include complete blood count, glucose, serum chemistry/electrolyte panel, thyroid function test, liver function test, renal function test, urinalysis, vitamin B12 and folate levels, HIV screening, syphilis screening, and pregnancy test, and when clinically indicated, an electrocardiogram (ECG), an electroencephalogram (EEG), a computed tomography (CT scan), and/or a magnetic resonance imagining (MRI) may be ordered.[13] Drug screening includes recreational drugs, particularly synthetic cannabinoids, and exposure to toxins.

Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV-TR)

Dx Code # Disorder Description
296.0x Bipolar I disorder Single manic episode
296.40 Bipolar I disorder Most recent episode hypomanic
296.4x Bipolar I disorder Most recent episode manic
296.5x Bipolar I disorder Most recent episode depressed
296.6x Bipolar I disorder Most recent episode mixed
296.7 Bipolar I disorder Most recent episode unspecified

Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)

In May 2013, American Psychiatric Association released the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). There are several proposed revisions to occur in the diagnostic criteria of Bipolar I Disorder and its subtypes. For Bipolar I Disorder 296.40 (most recent episode hypomanic) and 296.4x (most recent episode manic), the proposed revision includes the following specifiers: with psychotic features, with mixed features, with catatonic features, with rapid cycling, with anxiety (mild to severe), with suicide risk severity, with seasonal pattern, and with postpartum onset.[14] Bipolar I Disorder 296.5x (most recent episode depressed) will include all of the above specifiers plus the following: with melancholic features and with atypical features.[14] The categories for specifiers will be removed in DSM-5 and criterion A will add or there are at least 3 symptoms of major depression of which one of the symptoms is depressed mood or anhedonia.[14] For Bipolar I Disorder 296.7 (most recent episode unspecified), the listed specifiers will be removed.[14]

The criteria for manic and hypomanic episodes in criteria A & B will be edited. Criterion A will include "and present most of the day, nearly every day", and criterion B will include "and represent a noticeable change from usual behavior". These criteria as defined in the DSM-IV-TR have created confusion for clinicians and need to be more clearly defined.[15][16]

There have also been proposed revisions to criterion B of the diagnostic criteria for a Hypomanic Episode, which is used to diagnose For Bipolar I Disorder 296.40, Most Recent Episode Hypomanic. Criterion B lists "inflated self-esteem, flight of ideas, distractibility, and decreased need for sleep" as symptoms of a Hypomanic Episode. This has been confusing in the field of child psychiatry because these symptoms closely overlap with symptoms of attention deficit hyperactivity disorder (ADHD).[15]




Mood stabilizers are often used as part of the treatment process.[17]

  1. Lithium is the mainstay in the management of bipolar disorder but it has a narrow therapeutic range and typically requires monitoring[18]
  2. Anticonvulsants, such as valproate,[19] carbamazepine, or lamotrigine
  3. Atypical antipsychotics, such as quetiapine,[20][21] risperidone, olanzapine, or aripiprazole
  4. Electroconvulsive therapy, a psychiatric treatment in which seizures are electrically induced in anesthetized patients for therapeutic effect

Antidepressant-induced mania occurs in 20–40% of people with bipolar disorder. Mood stabilizers, especially lithium, may protect against this effect, but some research contradicts this.[22]

A frequent problem in these individuals is non-adherence to pharmacological treatment; long-acting injectable antipsychotics may contribute to solving this issue in some patients.[23]

A review of validated treatment guidelines for bipolar disorder by international bodies was published in 2020.[24]


Bipolar I usually has a poor prognosis, which is associated with substance abuse, psychotic features, depressive symptoms, and inter-episode depression.[25] A manic episode can be so severe that it requires hospitalization. An estimated 63% of all BP-I related mania results in hospitalization.[26] The natural course of BP-I, if left untreated, leads to episodes becoming more frequent or severe over time.[27] But with proper treatment, individuals with BP-I can lead a healthy lifestyle.[28]


Psychosocial interventions can be used for managing acute depressive episodes and for maintenance treatment to aid in relapse prevention.[29] This includes psychoeducation, cognitive behavioural therapy (CBT), family-focused therapy (FFT), interpersonal and social rhythm therapy (IPSRT), and peer support.[29]

Information on the condition, importance of regular sleep patterns, routines and eating habits and the importance of compliance with medication as prescribed. Behavior modification through counseling can have positive influence to help reduce the effects of risky behavior during the manic phase. Additionally, the lifetime prevalence for bipolar I disorder is estimated to be 1%.[30]

See also


  1. ^ "The Two Types of Bipolar Disorder". Psych Archived from the original on 6 August 2013. Retrieved 25 November 2015.
  2. ^ "Bipolar Disorder: Who's at Risk?". Retrieved 22 November 2011.
  3. ^ "Bipolar Disorder - National Institute of Mental Health (NIMH)". Retrieved 16 March 2024.
  4. ^ "What are the types of bipolar disorder?". Retrieved 22 November 2011.
  5. ^ Phillips, Mary L; Kupfer, David J (11 May 2013). "Bipolar disorder diagnosis: challenges and future directions". Lancet. 381 (9878): 1663–1671. doi:10.1016/S0140-6736(13)60989-7. ISSN 0140-6736. PMC 5858935. PMID 23663952.
  6. ^ a b "Online Bipolar Tests: How Much Can You Trust Them?". DepressionD. Retrieved 7 January 2012.
  7. ^ a b Diagnostic and statistical manual of mental disorders : DSM-5. American Psychiatric Association., American Psychiatric Association. DSM-5 Task Force. (Fifth ed.). Arlington, VA. 2013. ISBN 978-0-89042-559-6. OCLC 847226928.((cite book)): CS1 maint: location missing publisher (link) CS1 maint: others (link)
  8. ^ Khalsa, Hari-Mandir K.; Baldessarini, Ross J.; Tohen, Mauricio; Salvatore, Paola (11 August 2018). "Aggression among 216 patients with a first-psychotic episode of bipolar I disorder". International Journal of Bipolar Disorders. 6 (1): 18. doi:10.1186/s40345-018-0126-8. ISSN 2194-7511. PMC 6161985. PMID 30097737.
  9. ^ a b Cerimele, Joseph M.; Bauer, Amy M.; Fortney, John C.; Bauer, Mark S. (May 2017). "Patients With Co-Occurring Bipolar Disorder and Posttraumatic Stress Disorder: A Rapid Review of the Literature". The Journal of Clinical Psychiatry. 78 (5): e506–e514. doi:10.4088/JCP.16r10897. ISSN 1555-2101. PMID 28570791.
  10. ^ Hunt, Glenn E.; Malhi, Gin S.; Cleary, Michelle; Lai, Harry Man Xiong; Sitharthan, Thiagarajan (December 2016). "Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990–2015: Systematic review and meta-analysis". Journal of Affective Disorders. 206: 331–349. doi:10.1016/j.jad.2016.07.011. ISSN 1573-2517. PMID 27476137.
  11. ^ Léda-Rêgo, Gabriela; Studart-Bottó, Paula; Sarmento, Stella; Cerqueira-Silva, Thiago; Bezerra-Filho, Severino; Miranda-Scippa, Ângela (1 February 2023). "Psychiatric comorbidity in individuals with bipolar disorder: relation with clinical outcomes and functioning". European Archives of Psychiatry and Clinical Neuroscience. 273 (5): 1175–1181. doi:10.1007/s00406-023-01562-5. ISSN 0940-1334. PMID 36725737. S2CID 256501014.
  12. ^ "Bipolar Disorder Residential Treatment Center Los Angeles". PCH Treatment. Retrieved 25 November 2015.
  13. ^ a b Bobo, William V. (October 2017). "The Diagnosis and Management of Bipolar I and II Disorders: Clinical Practice Update". Mayo Clinic Proceedings. 92 (10): 1532–1551. doi:10.1016/j.mayocp.2017.06.022. ISSN 0025-6196. PMID 28888714.
  14. ^ a b c d American Psychiatric Association (22 May 2013). Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association. doi:10.1176/appi.books.9780890425596. ISBN 978-0-89042-555-8.
  15. ^ a b Issues pertinent to a developmental approach to bipolar disorder in DSM-5. American Psychiatric Association. 2010.
  16. ^ Diagnostic and Statistical Manual of Mental Disorders (4th ed. text revision). Washington, DC: American Psychiatric Association. 2000. pp. 345–392.
  17. ^ Schwartz, Jeremy (20 July 2017). "Can People Recover From Bipolar Disorder?". U.S. News & World Report.
  18. ^ Burgess, Sally SA; Geddes, John; Hawton, Keith KE; Taylor, Matthew J.; Townsend, Ellen; Jamison, K.; Goodwin, Guy (2001). "Lithium for maintenance treatment of mood disorders | Cochrane". Cochrane Database of Systematic Reviews. 2001 (3): CD003013. doi:10.1002/14651858.CD003013. PMC 7005360.
  19. ^ MacRitchie, Karine; Geddes, John; Scott, Jan; Haslam, D. R.; Silva De Lima, Mauricio; Goodwin, Guy (2003). "Valproate for acutre mood episodes in bipolar disorder | Cochrane". Cochrane Database of Systematic Reviews (1): CD004052. doi:10.1002/14651858.CD004052. PMID 12535506.
  20. ^ Datto, Catherine (11 March 2016). "Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression". Annals of General Psychiatry. 15: 9. doi:10.1186/s12991-016-0096-0. PMC 4788818. PMID 26973704.
  21. ^ Young, Allan (February 2014). "A Randomised, Placebo-Controlled 52-Week Trial of Continued Quetiapine Treatment in Recently Depressed Patients With Bipolar I And Bipolar II Disorder". World Journal of Biological Psychiatry. 15 (2): 96–112. doi:10.3109/15622975.2012.665177. PMID 22404704. S2CID 2224996.
  22. ^ Goldberg, Joseph F; Truman, Christine J (1 December 2003). "Antidepressant-induced mania: an overview of current controversies". Bipolar Disorders. 5 (6): 407–420. doi:10.1046/j.1399-5618.2003.00067.x. ISSN 1399-5618. PMID 14636364.
  23. ^ Tohen, Mauricio; Goldberg, Joseph F.; Hassoun, Youssef; Sureddi, Suresh (16 June 2020). "Identifying Profiles of Patients With Bipolar I Disorder Who Would Benefit From Maintenance Therapy With a Long-Acting Injectable Antipsychotic". The Journal of Clinical Psychiatry. 81 (4). doi:10.4088/JCP.OT19046AH1. ISSN 1555-2101. PMID 32558403. S2CID 219923839.
  24. ^ Verdolini, Norma; Hidalgo-Mazzei, Diego; Del Matto, Laura; Muscas, Michele; Pacchiarotti, Isabella; Murru, Andrea; Samalin, Ludovic; Aedo, Alberto; Tohen, Mauricio; Grunze, Heinz; Young, Allan H. (22 December 2020). "Long-term treatment of bipolar disorder type I: A systematic and critical review of clinical guidelines with derived practice algorithms". Bipolar Disorders. 23 (4): 324–340. doi:10.1111/bdi.13040. ISSN 1399-5618. PMID 33354842. S2CID 229693238.
  25. ^ Jain, A.; Mitra, P. (2023). "Bipolar Disorder". StatPearls. PMID 32644424.
  26. ^ De Zelicourt, M.; Dardennes, R.; Verdoux, H.; Gandhi, G.; Khoshnood, B.; Chomette, E.; Papatheodorou, M. L.; Edgell, E. T.; Even, C.; Fagnani, F. (2003). "Frequency of hospitalisations and inpatient care costs of manic episodes: In patients with bipolar I disorder in France". Pharmacoeconomics. 21 (15): 1081–1090. doi:10.2165/00019053-200321150-00002. PMID 14596627. S2CID 41439636.
  27. ^ "Bipolar Disorder – Fact Sheet".
  28. ^ "Living Well with Bipolar Disorder". 7 May 2019.
  29. ^ a b Yatham, Lakshmi N.; Kennedy, Sidney H.; Parikh, Sagar V.; Schaffer, Ayal; Bond, David J.; Frey, Benicio N.; Sharma, Verinder; Goldstein, Benjamin I.; Rej, Soham; Beaulieu, Serge; Alda, Martin (2018). "Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder". Bipolar Disorders. 20 (2): 97–170. doi:10.1111/bdi.12609. ISSN 1399-5618. PMC 5947163. PMID 29536616.
  30. ^ Merikangas, Kathleen R.; Akiskal, Hagop S.; Angst, Jules; Greenberg, Paul E.; Hirschfeld, Robert M.A.; Petukhova, Maria; Kessler, Ronald C. (1 May 2007). "Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication". Archives of General Psychiatry. 64 (5): 543–552. doi:10.1001/archpsyc.64.5.543. ISSN 0003-990X. PMC 1931566. PMID 17485606.