The following table lists all of the cities in the Midwestern United States with at least 100,000 people. These numbers were taken directly from the United States Census Bureau.[1] Note that only people living in the city itself are counted. People living in suburbs are not included.
| Rank | City | State | Census Population | Change | |
|---|---|---|---|---|---|
| 2020 | 2010 | ||||
| 1 | Chicago |  Illinois
|
2,746,388 | 2,695,598 | +1.9% |
| 2 | Columbus |  Ohio
|
905,748 | 787,033 | +15.1% |
| 3 | Indianapolis |  Indiana
|
887,642 | 820,445 | +8.2% |
| 4 | Detroit |  Michigan
|
639,111 | 713,777 | −10.5% |
| 5 | Milwaukee |  Wisconsin
|
577,222 | 594,833 | −3.0% |
| 6 | Kansas City |  Missouri
|
508,090 | 459,787 | +10.5% |
| 7 | Omaha |  Nebraska
|
486,051 | 408,958 | +18.9% |
| 8 | Minneapolis |  Minnesota
|
429,954 | 382,578 | +12.4% |
| 9 | Wichita |  Kansas
|
397,532 | 382,368 | +4.0% |
| 10 | Cleveland | Ohio
|
372,624 | 396,815 | −6.1% |
| 11 | Saint Paul | Minnesota
|
311,527 | 285,068 | +9.3% |
| 12 | Cincinnati | Ohio
|
309,317 | 296,943 | +4.2% |
| 13 | St. Louis | Missouri
|
301,578 | 319,294 | −5.5% |
| 14 | Lincoln | Nebraska
|
291,082 | 258,379 | +12.7% |
| 15 | Toledo | Ohio
|
270,871 | 287,208 | −5.7% |
| 16 | Madison | Wisconsin
|
269,840 | 233,209 | +15.7% |
| 17 | Fort Wayne | Indiana
|
263,886 | 253,691 | +4.0% |
| 18 | Des Moines |  Iowa
|
214,133 | 203,433 | +5.3% |
| 19 | Grand Rapids | Michigan
|
198,917 | 188,040 | +5.8% |
| 20 | Overland Park | Kansas
|
197,238 | 173,372 | +13.8% |
| 21 | Sioux Falls |  South Dakota
|
192,517 | 153,888 | +25.1% |
| 22 | Akron | Ohio
|
190,469 | 199,110 | −4.3% |
| 23 | Aurora | Illinois
|
180,542 | 197,899 | −8.8% |
| 24 | Springfield | Missouri
|
169,176 | 159,498 | +6.1% |
| 25 | Kansas City | Kansas
|
156,607 | 145,786 | +7.4% |
| 26 | Joliet | Illinois
|
150,362 | 147,433 | +2.0% |
| 27 | Naperville | Illinois
|
149,540 | 141,853 | +5.4% |
| 28 | Rockford | Illinois
|
148,655 | 152,871 | −2.8% |
| 29 | Olathe | Kansas
|
141,290 | 125,872 | +12.2% |
| 30 | Warren | Michigan
|
139,387 | 134,056 | +4.0% |
| 31 | Cedar Rapids | Iowa
|
137,710 | 126,326 | +9.0% |
| 32 | Dayton | Ohio
|
137,644 | 141,527 | −2.7% |
| 33 | Sterling Heights | Michigan
|
134,346 | 129,699 | +3.6% |
| 34 | Topeka | Kansas
|
126,587 | 127,473 | −0.7% |
| 35 | Columbia | Missouri
|
126,254 | 108,500 | +16.4% |
| 36 | Fargo |  North Dakota
|
125,990 | 105,549 | +19.4% |
| 37 | Ann Arbor | Michigan
|
123,851 | 113,934 | +8.7% |
| 38 | Independence | Missouri
|
123,011 | 116,830 | +5.3% |
| 39 | Rochester | Minnesota
|
121,395 | 106,769 | +13.7% |
| 40 | Evansville | Indiana
|
117,298 | 117,429 | −0.1% |
| 41 | Elgin | Illinois
|
114,797 | 108,188 | +6.1% |
| 42 | Springfield | Illinois
|
114,394 | 116,250 | −1.6% |
| 43 | Peoria | Illinois
|
113,150 | 115,007 | −1.6% |
| 44 | Lansing | Michigan
|
112,644 | 114,297 | −1.4% |
| 45 | Dearborn | Michigan
|
109,976 | 98,153 | +12.0% |
| 46 | Green Bay | Wisconsin
|
107,395 | 104,057 | +3.2% |
| 47 | South Bend | Indiana
|
103,453 | 101,168 | +2.3% |
| 48 | Davenport | Iowa
|
101,724 | 99,685 | +2.0% |
| 49 | Lee's Summit | Missouri
|
101,108 | 91,364 | +10.7% |
| 50 | Clinton Township | Michigan
|
100,513 | 96,796 | +3.8% |