Illustration of two groups: one exposed to a risk factor, and one unexposed. Exposed group has larger risk of adverse outcome (NNH = 4).
Group exposed to a risk factor (left) has increased risk of an adverse outcome (black) compared to the unexposed group (right). 4 individuals need to be exposed for 1 adverse outcome to occur (NNH = 4).

In medicine, the number needed to harm (NNH) is an epidemiological measure that indicates how many persons on average need to be exposed to a risk factor over a specific period to cause harm in an average of one person who would not otherwise have been harmed. It is defined as the inverse of the absolute risk increase, and computed as , where is the incidence in the treated (exposed) group, and is the incidence in the control (unexposed) group.[1] Intuitively, the lower the number needed to harm, the worse the risk factor, with 1 meaning that every exposed person is harmed.

NNH is similar to number needed to treat (NNT), where NNT usually refers to a positive therapeutic result and NNH to a detrimental effect or risk factor.

Marginal metrics:

are also used.[2]

Relevance

The NNH is an important measure in evidence-based medicine and helps physicians decide whether it is prudent to proceed with a particular treatment which may expose the patient to harms while providing therapeutic benefits. If a clinical endpoint is devastating enough without the drug (e.g. death, heart attack), drugs with a low NNH may still be indicated in particular situations if the NNT is smaller than the NNH.[dubious – discuss][citation needed] However, there are several important problems with the NNH, involving bias and lack of reliable confidence intervals, as well as difficulties in excluding the possibility of no difference between two treatments or groups.[3]

Numerical example

Example of risk increase
Quantity Experimental group (E) Control group (C) Total
Events (E) EE = 75 CE = 100 175
Non-events (N) EN = 75 CN = 150 225
Total subjects (S) ES = EE + EN = 150 CS = CE + CN = 250 400
Event rate (ER) EER = EE / ES = 0.5, or 50% CER = CE / CS = 0.4, or 40% —
Variable Abbr. Formula Value
Absolute risk increase ARI EER − CER 0.1, or 10%
Number needed to harm NNH 1 / (EER − CER) 10
Relative risk (risk ratio) RR EER / CER 1.25
Relative risk increase RRI (EER − CER) / CER, or RR − 1 0.25, or 25%
Attributable fraction among the exposed AFe (EER − CER) / EER 0.2
Odds ratio OR (EE / EN) / (CE / CN) 1.5

See also

References

  1. ^ Porta, Miquel; Greenland, Sander; Hernán, Miguel; Silva, Isabel dos Santos; Last, John M. (2014). Dictionary of Epidemiology - Oxford Reference. doi:10.1093/acref/9780199976720.001.0001. ISBN 9780199976720.
  2. ^ Schünemann, Holger J (2023). "Cochrane Handbook for Systematic Reviews of Interventions". cochrane.org. Cochrane Training. Retrieved 3 October 2023. [NNH] can easily[citation needed] be read to imply the number of people who will experience a harmful outcome if given the intervention ... The preferred alternative is to use phrases such as 'number needed to treat for an additional beneficial outcome' (NNTB) and 'number needed to treat for an additional harmful outcome' (NNTH) to indicate direction of effect.
  3. ^ Hutton JL (2010). "Misleading Statistics: The Problems Surrounding Number Needed to Treat and Number Needed to Harm". Pharm Med. 24 (3): 145–9. doi:10.1007/BF03256810. S2CID 39801240.
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