Protein-coding gene in the species Homo sapiens
PRPF8 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3E9L, 3ENB, 3LRU, 4JK7, 4JK8, 4JK9, 4JKA, 4JKB, 4JKC, 4JKD, 4JKE, 4JKF, 4JKG, 4JKH, 4KIT, 3JCR |
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Identifiers |
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Aliases | PRPF8, pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220 |
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External IDs | OMIM: 607300 MGI: 2179381 HomoloGene: 4706 GeneCards: PRPF8 |
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Wikidata |
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Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.[5][6]
Function
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.[7]
Interactions
PRPF8 has been shown to interact with WDR57[8][9] and EFTUD2.[9]