The Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Leading Role in a Motion Picture is an award given by the Screen Actors Guild to honor the finest acting achievements in film.
Multiple nominees
Note: Winners are indicated in bold type.
- Two nominations
- Amy Adams (Arrival (2016), Hillbilly Elegy (2020))
- Joan Allen (Nixon (1995), The Contender (2000))
- Emily Blunt (The Girl On The Train (2016), Mary Poppins Returns (2018))
- Sandra Bullock (The Blind Side (2009), Gravity (2013))
- Jessica Chastain (Zero Dark Thirty (2012), The Eyes of Tammy Faye (2021))
- Glenn Close (Albert Nobbs (2011), The Wife (2018))
- Olivia Colman (The Favourite (2018), The Lost Daughter (2021))
- Marion Cotillard (La Vie en Rose (2007), Rust and Bone (2012))
- Lady Gaga (A Star is Born (2018), House of Gucci (2021))
- Angelina Jolie (A Mighty Heart (2007), Changeling (2008))
- Diane Keaton (Marvin's Room (1996), Something's Gotta Give (2003))
- Jennifer Lawrence (Winter's Bone (2010), Silver Linings Playbook (2012))
- Carey Mulligan (An Education (2009), Promising Young Woman (2020))
- Natalie Portman (Black Swan (2010), Jackie (2016))
- Saoirse Ronan (Brooklyn (2015), Lady Bird (2017))
- Susan Sarandon (The Client (1994), Dead Man Walking (1995))
- Emma Thompson (Sense and Sensibility (1995), Saving Mr. Banks (2013))
- Naomi Watts (21 Grams (2003), The Impossible (2012))
- Reese Witherspoon (Walk the Line (2005), Wild (2014))
- Three nominations
- Annette Bening (American Beauty (1999), Being Julia (2004), The Kids Are All Right (2010))
- Viola Davis (The Help (2011), Ma Rainey's Black Bottom (2020), The Woman King (2022))
- Nicole Kidman (The Hours (2002), Rabbit Hole (2010), Being the Ricardos (2021))
- Frances McDormand (Fargo (1996), Three Billboards Outside Ebbing, Missouri (2017), Nomadland (2020))
- Julianne Moore (The End of the Affair (1999), Far from Heaven (2002), Still Alice (2014))
- Hilary Swank (Boys Don't Cry (1999), Million Dollar Baby (2004), Conviction (2010))
- Charlize Theron (Monster (2003), North Country (2005), Bombshell (2019))
- Renée Zellweger (Bridget Jones's Diary (2001), Chicago (2002), Judy (2019))
- Four nominations
- Helen Mirren (The Queen (2006), The Last Station (2009), Hitchcock (2012), Woman in Gold (2015))
- Kate Winslet (Titanic (1997), Eternal Sunshine of the Spotless Mind (2004), Little Children (2006), Revolutionary Road (2008))
- Five nominations
- Cate Blanchett (Elizabeth (1998), Elizabeth: The Golden Age (2007), Blue Jasmine (2013), Carol (2015), Tár (2022))
- Six nominations
- Judi Dench (Mrs Brown (1997), Iris (2001), Mrs Henderson Presents (2005), Notes on a Scandal (2006), Philomena (2013), Victoria & Abdul (2017))
- Ten nominations
- Meryl Streep (The River Wild (1994), The Bridges of Madison County (1995), One True Thing (1998), Music of the Heart (1999), The Devil Wears Prada (2006), Doubt (2008), Julie & Julia (2009), The Iron Lady (2011), August: Osage County (2013), Florence Foster Jenkins (2016))