Apoptosis signaling pathway

Fas path

Ligand

Fas ligand

Receptor

Fas receptor

Intracellular

Death-inducing signaling complex DAXX ASK1 FADD Caspase 8 BID Cytochrome c Caspase 9 Caspase 3
Bcl-2 family	Pro-apoptotic: BAX BAK1/Bcl-2 homologous antagonist killer Bcl-2-associated death promoter Anti-apoptotic: Bcl-2 Bcl-xL

TNF path

Ligand	Tumor necrosis factor alpha
Receptor	Tumor necrosis factor receptor 1 Tumor necrosis factor receptor 2
Intracellular	TRADD FADD Caspase 8 Caspase 3 BID TRAF2 ASK-1 MEKK1 IKK IκBα MKK7 JNK NF-κB

Other

Intracellular	IAPs XIAP NAIP Survivin c-IAP-1 c-IAP-2 Apoptosis-inducing factor

Category