Hemokin (C-C motiv) ligand 22

Identifikatori

CCL22; MDC; A-152E5.1; ABCD-1; DC/B-CK; MGC34554; SCYA22; STCP-1

Vanjski ID

OMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCards: CCL22 Gene

Ontologija gena
Molekularna funkcija	• hemokinska aktivnost
Celularna komponenta	• ekstracelularni region • ekstracelularni prostor
Biološki proces	• hemotaksa • inflamatorni odgovor • imunski odgovor • transdukcija signala • interćelijska signalizacija • respons na viruse • antimikrobni humoralni respons

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 16:
55.95 - 55.96 Mb

Chr 8:
97.63 - 97.64 Mb

PubMed pretraga

[1]

[2]

CCL22, hemokin (C-C motiv) ligand 22, je protein koji je kod ljudi kodiran CCL22 genom.^[1]^[2]^[3]^[4]

Ovaj protein izlučuju dendritske ćelije i makrofage. On dejstvuje na svoje ciljne ćelije target putem interakcija sa hemokinski receptorima na ćelijskoj površini kao što je CCR4.^[5] CCL22 gen je lociran na ljudskom hromozomu 16 u klasteru sa drugim hemokinima: CX3CL1 i CCL17.^[6]^[7]

Reference

^ Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (1997). „Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells”. J Exp Med. 185 (9): 1595—604. PMC 2196293 . PMID 9151897.
^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13”. Cytogenet Cell Genet. 81 (1): 10—1. PMID 9691168.
^ „Entrez Gene: CCL22 chemokine (C-C motif) ligand 22”.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001). „Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo”. Eur. J. Immunol. 31 (3): 812—22. PMID 11241286. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L.
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q”. Genomics. 60 (3): 295—308. PMID 10493829. doi:10.1006/geno.1999.5927.
^ Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). „Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13”. Cytogenet. Cell Genet. 81 (1): 10—1. PMID 9691168. doi:10.1159/000015000.

Literatura

Robertson MJ (2002). „Role of chemokines in the biology of natural killer cells.”. J. Leukoc. Biol. 71 (2): 173—83. PMID 11818437.
Gear AR, Camerini D (2003). „Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense.”. Microcirculation (New York, N.Y. : 1994). 10 (3-4): 335—50. PMID 12851650. doi:10.1038/sj.mn.7800198.
Chang M; McNinch J; Elias C; et al. (1997). „Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes.”. J. Biol. Chem. 272 (40): 25229—37. PMID 9312138. doi:10.1074/jbc.272.40.25229.
Pal R; Garzino-Demo A; Markham PD; et al. (1997). „Inhibition of HIV-1 infection by the beta-chemokine MDC.”. Science. 278 (5338): 695—8. PMID 9381181. doi:10.1126/science.278.5338.695.
Imai T; Chantry D; Raport CJ; et al. (1998). „Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.”. J. Biol. Chem. 273 (3): 1764—8. PMID 9430724. doi:10.1074/jbc.273.3.1764.
Struyf S; Proost P; Sozzani S; et al. (1998). „Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.”. J. Immunol. 161 (6): 2672—5. PMID 9743322.
Meucci O; Fatatis A; Simen AA; et al. (1998). „Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.”. Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14500—5. PMC 24402 . PMID 9826729. doi:10.1073/pnas.95.24.14500.
Proost P; Struyf S; Schols D; et al. (1999). „Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction.”. J. Biol. Chem. 274 (7): 3988—93. PMID 9933589. doi:10.1074/jbc.274.7.3988.
Loftus BJ; Kim UJ; Sneddon VP; et al. (1999). „Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.”. Genomics. 60 (3): 295—308. PMID 10493829. doi:10.1006/geno.1999.5927.
Annunziato F; Romagnani P; Cosmi L; et al. (2000). „Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.”. J. Immunol. 165 (1): 238—46. PMID 10861057.
Vulcano M; Albanesi C; Stoppacciaro A; et al. (2001). „Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.”. Eur. J. Immunol. 31 (3): 812—22. PMID 11241286. doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L.
Berin MC, Dwinell MB, Eckmann L, Kagnoff MF (2001). „Production of MDC/CCL22 by human intestinal epithelial cells.”. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (6): G1217—26. PMID 11352815.
Lambeir AM; Proost P; Durinx C; et al. (2001). „Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.”. J. Biol. Chem. 276 (32): 29839—45. PMID 11390394. doi:10.1074/jbc.M103106200.
Wakahara S; Fujii Y; Nakao T; et al. (2002). „Gene expression profiles for Fc epsilon RI, cytokines and chemokines upon Fc epsilon RI activation in human cultured mast cells derived from peripheral blood.”. Cytokine. 16 (4): 143—52. PMID 11792124. doi:10.1006/cyto.2001.0958.
Ghia P; Strola G; Granziero L; et al. (2002). „Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22.”. Eur. J. Immunol. 32 (5): 1403—13. PMID 11981828. doi:10.1002/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y.
D'Ambrosio D; Albanesi C; Lang R; et al. (2002). „Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion.”. J. Immunol. 169 (5): 2303—12. PMID 12193695.
Campbell JD, Stinson MJ, Simons FE, HayGlass KT (2003). „Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans.”. Int. Immunol. 14 (11): 1255—62. PMID 12407016. doi:10.1093/intimm/dxf098.

Spoljašnje veze

CCL22 GeneCard

Ćelijska komunikacija: Citokini

Po familiji

Interleukin

IL-1 superfamilija	1 (1Ra) 18 33
poput IL-6/gp130 koristeći	6 11 27 30 31 (+ne IL Onkostatin M Inhibitorni faktor leukemije Cilijarni neurotrofni faktor Kardiotrofin 1)
IL-10 familija	10 19 20 22 24 26
Interferon tip III	28 29
Zajednički γ-lanac familija	2/15 3 4 7 9 13 21
IL-12 familija	12 (B) 23 27 35
Drugi	5 8 14 16 17/25 (A) 32 34

Hemokini

CCL	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
CXCL	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
CX3CL	1
XCL	1 2

TNF

Glavni	TNF-alfa
TNF (ligand) superfamilija	4-1BB ligand Faktor aktivacije B-ćelija FAS ligand Limfotoksin OX40L RANKL TRAIL
Klaster diferencijacije	CD70 CD153 CD154

Interferon

I	alfa ( Pegilirani 2a Pegilirani 2b), beta (1a 1b)
II	Gama
III	IL-28 IL-29

Drugi

Po funkciji

Категорије