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ECHA InfoCard | 100.048.694 |
Chemical and physical data | |
Formula | C18H17ClN2O3 |
Molar mass | 344.80 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Arfendazam (INN)[1] is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.
Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses.[2][3]
Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.[4]
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* atypical activity profile (not GABAA receptor ligands) |
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