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Formula | C17H13BrN4 |
Molar mass | 353.223 g·mol−1 |
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Bromazolam (XLI-268) is a triazolobenzodiazepine (TBZD) which was first synthesised in 1976, but was never marketed.[2] It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016.[3] It is the bromo instead of chloro analogue of alprazolam and has similar sedative and anxiolytic effects to it and other benzodiazepines.[4][5] Bromazolam is a non subtype selective agonist at the benzodiazepine site of GABAA receptors, with a binding affinity of 2.81nM at the α1 subtype, 0.69nM at α2 and 0.62nM at α5.[6] The "common" dosage range for users of bromazolam was reported to be 1–2 mg, suggesting its potency is similar to alprazolam.[7]
In the United States, Bromazolam is unscheduled at the federal level. However a number of states such as Virginia have placed Bromazolam into Schedule 1 at the state level but does not include the chloro analog Phenazolam.[8][9]
Despite being unscheduled there have been several arrests in the United States for mismarketing Bromazolam as Alprazolam, typically in the shape of brand name Xanax tablets which constitutes a counterfeit drug charge among others.[10]
In Illinois, at least 1 person has been arrested for "unlawful possession of a controlled substance, a Class 4 felony." for the possession of less than 15 grams (½ oz) of Bromazolam, similar to being charged for unlawful possession of Alprazolam in Illinois. It's unknown if this arrest involved counterfeit Xanax shaped tablets or powder.[11] However Bromazolam is not scheduled in Illinois.[12]
In June 2022, the U.S. Department of Justice reported that bromazolam seizures were "surging" across the United States, driven in part by increasing detections alongside fentanyl.[13] Illicit opioids such as heroin or fentanyl analogues are mixed with bromazolam and sold at the street level; the product is sometimes referred to as "benzo-dope."[14] The Indiana Department of Health reported that bromazolam represented 73% of all novel or designer benzodiazepines detected in the first six months of 2023. Of 1,051 blood toxicology samples containing bromazolam reported between January and June 2023, 83% were fentanyl positive, suggesting that bromazolam is commonly mixed with fentanyl.[15]
In the United Kingdom, Bromazolam is a Class C controlled substance.