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Formula | C15H16N4O2 |
Molar mass | 284.319 g·mol−1 |
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Zomebazam[1] produced by Hoechst is a pyrazolodiazepinone derivative drug with anxiolytic properties. It is structurally related to razobazam and zometapine.[2]
The catalytic hydrogenation of N,2,5-trimethyl-4-phenyldiazenylpyrazol-3-amine CID:136203602 (1) over Raney Nickel gives 4-amino-1,3-dimethyl-5-methylaminopyrazole, CID:10219477 (2). Treatment with methyl malonyl chloride [37517-81-0] (3) gives 4-a-ethoxycarbonylacetylamino-1,3-dimethyl-5-methylaminopyrazole, CID:20561101 (4). Base catalyzed lactamization gives (5). The Goldberg reaction completes the synthesis Zomebazam (6).