Protein-coding gene in the species Homo sapiens
KCNJ12 |
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Identifiers |
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Aliases | KCNJ12, IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x, potassium voltage-gated channel subfamily J member 12, potassium inwardly rectifying channel subfamily J member 12 |
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External IDs | OMIM: 602323 MGI: 108495 HomoloGene: 7793 GeneCards: KCNJ12 |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - cerebellar vermis
- cerebellar hemisphere
- gastrocnemius muscle
- quadriceps femoris muscle
- vastus lateralis muscle
- tibialis anterior muscle
- deltoid muscle
- spinal ganglia
- body of tongue
- left ventricle
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| Top expressed in | - cerebellar cortex
- sternocleidomastoid muscle
- lens
- triceps brachii muscle
- skeletal muscle tissue
- knee joint
- temporal muscle
- quadriceps femoris muscle
- superior frontal gyrus
- extensor digitorum longus muscle
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| More reference expression data |
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BioGPS | |
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Wikidata |
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ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.[5][6][7][8][9]
Function
This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith–Magenis syndrome region on chromosome 17.[9]