The United States Drug Enforcement Administration (DEA) maintains lists regarding the classification of illicit drugs (see DEA Schedules). It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs. The list is designated within the Controlled Substances Act[1] but can be modified by the U.S. Attorney General as illegal manufacturing practices change.

Although the list is controlled by the Attorney General, the list is considered a DEA list because the DEA publishes and enforces the list.

Suppliers of these products are subject to regulation and control measures:[2]

Regulation List I List II Tableting and Encapsulating Machines Special Surveillance List
Know your customer X X X X
Annual manufacturing, inventory, and use reports for bulk manufacturers X X X
15 day advanced DEA notice required for imports, exports, and transshipments X X
15 day advanced DEA notice required for international transactions X X
Keep transaction records for at least two years X X
Maintain effective security controls X X
Required reporting for unusual sales and losses or sales to DEA-identified companies X X
Registration required for manufacturing, distribution, import, or export X
Reports of mail-order sales to non-regulated entities X

List I chemicals

These chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances:[3]

Chemical Illicit drug
Alpha-phenylacetoacetonitrile and its salts, optical isomers, and salts of optical isomers (APAAN) phenylacetone, methamphetamine, amphetamine
Anthranilic acid, its esters, and its salts methaqualone and analogues
Benzyl cyanide phenylacetic acid, phenylacetone, amphetamine
Ephedrine, its salts, optical isomers, and salts of optical isomers methamphetamine
Ergonovine and its salts lysergic acid diethylamide
Ergotamine and its salts lysergic acid diethylamide
N-Acetylanthranilic acid, its esters, and its salts methaqualone
Norpseudoephedrine, its salts, optical isomers, and salts of optical isomers amphetamine
Phenylacetic acid, its esters, and its salts phenylacetone, amphetamine, methamphetamine
Phenylpropanolamine, its salts, optical isomers, and salts of optical isomers amphetamine, methamphetamine
Piperidine and its salts phencyclidine and analogues
Pseudoephedrine, its salts, optical isomers, and salts of optical isomers methamphetamine
3,4-Methylenedioxyphenyl-2-propanone MDMA, MDA, MDEA, MDOH
Methylamine and its salts methamphetamine
Ethylamine and its salts etilamfetamine
Propionic anhydride fentanyl
Isosafrole MDMA, MDA
Safrole MDMA, MDA
Piperonal MDMA, MDA
N-Methylephedrine, its salts, optical isomers, and salts of optical isomers methamphetamine
N-Methylpseudoephedrine, its salts, optical isomers, and salts of optical isomers methamphetamine
Hydroiodic acid methamphetamine, amphetamine
Benzaldehyde methamphetamine, amphetamine
Nitroethane methamphetamine, amphetamine
Gamma butyrolactone (other names include: GBL; dihydro-2(3H)-furanone; 1,2-butanolide; 1,4-butanolide; 4-hydroxybutanoic acid lactone; gamma-hydroxybutyric acid lactone) Gamma-Hydroxybutyric acid (GHB)
Red phosphorus methamphetamine, amphetamine
White phosphorus (other names: yellow phosphorus) methamphetamine, amphetamine
Hypophosphorous acid and its salts (including ammonium hypophosphite, calcium hypophosphite, iron hypophosphite, potassium hypophosphite, manganese hypophosphite, magnesium hypophosphite and sodium hypophosphite) methamphetamine, amphetamine
N-Phenethyl-4-piperidone (NPP) fentanyl
Iodine methamphetamine, amphetamine
Ergocristine and its salts lysergic acid diethylamide
N-(1-benzylpiperidin-4-yl)-N-phenylpropionamide (benzylfentanyl) and its salts fentanyl
N-phenylpiperidin-4-amine(4-anilinopiperidine; N-phenyl-4-piperidinamine; 4-AP), its amides, its carbamates, and its salts fentanyl
3,4-MDP-2-P methyl glycidate (PMK glycidate) and its optical and geometric isomers MDMA and other "ecstasy"-type substances
3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid) and its salts, optical and geometric isomers, and salts of isomers MDMA and other "ecstasy"-type substances
Alpha-phenylacetoacetamide (APAA) and its optical isomers amphetamine, methamphetamine
Methyl alpha-phenylacetoacetate (MAPA; methyl 3-oxo-2-phenylbutanoate) and its optical isomers phenylacetone, methamphetamine, amphetamine

List II chemicals

These chemicals are designated as those that are used in the manufacture of controlled substances:[4]

  1. Acetic anhydride
  2. Acetone
  3. Benzyl chloride
  4. Diethyl ether
  5. Potassium permanganate
  6. 2-Butanone (or methyl ethyl ketone or MEK)
  7. Toluene
  8. Hydrochloric acid (including anhydrous hydrogen chloride)
  9. Sulfuric acid
  10. Methyl isobutyl ketone (MIBK)
  11. Sodium permanganate

Special Surveillance List

Chemicals

All listed chemicals[5] as specified in 21 CFR 1310.02 (a) or (b). This includes supplements which contain a listed chemical, regardless of their dosage form or packaging and regardless of whether the chemical mixture, drug product or dietary supplement is exempt from regulatory controls. For each chemical, its illicit manufacturing use is given in parentheses. Some Special Surveillance List chemicals do not have an exclusive manufacturing use for a specific illicit drug but rather have a broad range of uses in both legitimate and illicit manufacturing operations.

Chemical Illicit drug
Ammonia gas amphetamine, methamphetamine
Ammonium formate amphetamine, methamphetamine
Bromobenzene phencyclidine
Carbonyldiimidazole lysergic acid diethylamide
Cyclohexanone phencyclidine
1,1-Dichloro-1-fluoroethane (aka freon 141B)
Diethylamine and its salts lysergic acid diethylamide
2,5-Dimethoxyphenethylamine and its salts (2C-B, 2C-C, 2C-I, 2C-N)
Formamide amphetamine, methamphetamine
Formic acid amphetamine, methamphetamine
Lithium metal amphetamine, methamphetamine
Lithium aluminum hydride amphetamine, methamphetamine
Magnesium metal (turnings) phencyclidine
Mercuric chloride amphetamine, methamphetamine
N-Methylformamide amphetamine, methamphetamine
Organomagnesium halides (Grignard reagents) (e.g. ethylmagnesium bromide and phenylmagnesium bromide) phencyclidine
Phenylethanolamine and its salts
Phosphorus pentachloride lysergic acid diethylamide
Potassium dichromate general-purpose oxidizing agent
Pyridine and its salts general-purpose solvent
Sodium dichromate general-purpose oxidizing agent
Sodium metal phenylacetone
Thionyl chloride lysergic acid diethylamide
ortho-Toluidine methaqualone
Trichloromonofluoromethane (aka freon-11, carrene-2)
1,1,2-Trichloro-1,2,2-trifluoroethane (aka freon 113)

Equipment

The equipment list:[5]

References

  1. ^ 21 U.S.C. § 802, paragraphs 34 (list I) and 35 (list II)
  2. ^ DEA (2013). "Chemical Handler's Manual" (PDF). usdoj.gov. Archived from the original (PDF) on 2017-04-27. Retrieved 2017-05-05.
  3. ^ "eCFR :: 21 CFR 1310.02 -- Substances covered". 2022-05-11. Archived from the original on 11 May 2022. Retrieved 2022-05-12.
  4. ^ "Archived copy". Archived from the original on December 15, 2014. Retrieved August 28, 2014.((cite web)): CS1 maint: archived copy as title (link)
  5. ^ a b "Archived copy". Archived from the original on April 20, 2011. Retrieved May 20, 2011.((cite web)): CS1 maint: archived copy as title (link)

See also