In music, a **ditone** (Latin: *ditonus*, from Ancient Greek: δίτονος, "of two tones") is the interval of a major third. The size of a ditone varies according to the sizes of the two tones of which it is compounded. The largest is the Pythagorean ditone, with a ratio of 81:64, also called a comma-redundant major third; the smallest is the interval with a ratio of 100:81, also called a comma-deficient major third.^{[1]}

The **Pythagorean ditone** is the major third in Pythagorean tuning, which has an interval ratio of 81:64,^{[2]} which is 407.82 cents. The Pythagorean ditone is evenly divisible by two major tones (9/8 or 203.91 cents) and is wider than a just major third (5/4, 386.31 cents) by a syntonic comma (81/80, 21.51 cents). Because it is a comma wider than a "perfect" major third of 5:4, it is called a "comma-redundant" interval.^{[3]} Play (help·info)

"The major third that appears commonly in the [Pythagorean] system (C–E, D–F♯, etc.) is more properly known as the Pythagorean ditone and consists of two major and two minor semitones (2M+2m). This is the interval that is extremely sharp, at 408c (the *pure* major third is only 386c)."^{[4]}

It may also be thought of as four justly tuned fifths minus two octaves.

The prime factorization of the 81:64 ditone is 3^4/2^6 (or 3/1 * 3/1 * 3/1 * 3/1 * 1/2 * 1/2 * 1/2 * 1/2 * 1/2 * 1/2).

In Didymus's diatonic and Ptolemy's syntonic tunings, the ditone is a just major third with a ratio of 5:4, made up of two unequal tones—a major and a minor tone of 9:8 and 10:9, respectively. The difference between the two systems is that Didymus places the minor tone below the major, whereas Ptolemy does the opposite.^{[5]}

In meantone temperaments, the major tone and minor tone are replaced by a "mean tone" which is somewhere in between the two. Two of these tones make a ditone or major third. This major third is exactly the just (5:4) major third in quarter-comma meantone. This is the source of the name: the note exactly halfway between the bounding tones of the major third is called the "mean tone".^{[6]}

Modern writers occasionally use the word "ditone" to describe the interval of a major third in equal temperament.^{[7]} For example, "In modern acoustics, the equal-tempered semitone has 100 cents, the tone 200 cents, the ditone or major third 400 cents, the perfect fourth 500 cents, and so on. …”^{[8]}