Protein-coding gene in the species Homo sapiens
Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene .[5] [6]
Retrovirus receptors allow infection of human and murine cells by various retroviruses . The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus , Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter .[supplied by OMIM][6]
Research
It was reported that mutations of the gene may cause epispadias or bladder exstrophy .[7]
Takeuchi Y, Vile RG, Simpson G, et al. (1992). "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus" . J. Virol . 66 (2): 1219–22. doi :10.1128/JVI.66.2.1219-1222.1992 . PMC 240831 . PMID 1309898 .
Johann SV, Gibbons JJ, O'Hara B (1992). "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus" . J. Virol . 66 (3): 1635–40. doi :10.1128/JVI.66.3.1635-1640.1992 . PMC 240899 . PMID 1531369 .
Kaelbling M, Eddy R, Shows TB, et al. (1991). "Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2" . J. Virol . 65 (4): 1743–7. doi :10.1128/JVI.65.4.1743-1747.1991 . PMC 239979 . PMID 1672162 .
O'Hara B, Johann SV, Klinger HP, et al. (1991). "Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus". Cell Growth Differ . 1 (3): 119–27. PMID 2078500 .
Olah Z, Lehel C, Anderson WB, et al. (1994). "The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter" . J. Biol. Chem . 269 (41): 25426–31. doi :10.1016/S0021-9258(18)47267-5 . PMID 7929240 .
Miller DG, Miller AD (1994). "A family of retroviruses that utilize related phosphate transporters for cell entry" . J. Virol . 68 (12): 8270–6. doi :10.1128/JVI.68.12.8270-8276.1994 . PMC 237294 . PMID 7966619 .
Johann SV, van Zeijl M, Cekleniak J, O'Hara B (1993). "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species" . J. Virol . 67 (11): 6733–6. doi :10.1128/JVI.67.11.6733-6736.1993 . PMC 238113 . PMID 8411375 .
Tatsumi S, Segawa H, Morita K, et al. (1998). "Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands" . Endocrinology . 139 (4): 1692–9. doi :10.1210/endo.139.4.5925 . PMID 9528951 .
Palmer G, Manen D, Bonjour JP, Caverzasio J (1999). "Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region". Gene . 226 (1): 25–33. doi :10.1016/S0378-1119(98)00572-1 . PMID 9889306 .
Jono S, McKee MD, Murry CE, et al. (2000). "Phosphate regulation of vascular smooth muscle cell calcification" . Circ. Res . 87 (7): E10–7. doi :10.1161/01.RES.87.7.e10 . PMID 11009570 .
Farrell KB, Russ JL, Murthy RK, Eiden MV (2002). "Reassessing the role of region A in Pit1-mediated viral entry" . J. Virol . 76 (15): 7683–93. doi :10.1128/JVI.76.15.7683-7693.2002 . PMC 136385 . PMID 12097582 .
Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function" . J. Biol. Chem . 277 (45): 42741–7. doi :10.1074/jbc.M207096200 . PMID 12205090 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways" . Oncogene . 22 (21): 3307–18. doi :10.1038/sj.onc.1206406 . PMID 12761501 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R (2005). "Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes" . Arthritis Rheum . 52 (1): 144–54. doi :10.1002/art.20748 . PMID 15641067 .
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31. Bibcode :2005Natur.434..724H . doi :10.1038/nature03466 . PMID 15815621 .
Li X, Yang HY, Giachelli CM (2006). "Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification" . Circ. Res . 98 (7): 905–12. doi :10.1161/01.RES.0000216409.20863.e7 . PMID 16527991 .
Bøttger P, Hede SE, Grunnet M, et al. (2007). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2". Am. J. Physiol., Cell Physiol . 291 (6): C1377–87. doi :10.1152/ajpcell.00015.2006 . PMID 16790504 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11):
proton coupled metal ion transporter
(12): (13):
human Na+ -sulfate/carboxylate cotransporter
(14): (15):
proton oligopeptide cotransporter
(16):
monocarboxylate transporter
(17): (18): (19): (20):
SLC21–30
(21): (22): (23):
Na+-dependent ascorbic acid transporter
(24): (25): (26):
multifunctional anion exchanger
(27): (28):
Na+ -coupled nucleoside transport (SLC28A1
(29):
facilitative nucleoside transporter
(30):
SLC31–40
(31): (32): (33): (34):
type II Na+ -phosphate cotransporter
(35):
nucleoside-sugar transporter
SLC35E1
SLC35E2
SLC35E3
SLC35E4
(36):
proton-coupled amino-acid transporter
(37):
sugar-phosphate/phosphate exchanger
(38):
System A & N, sodium-coupled neutral amino-acid transporter
(39): (40):
basolateral iron transporter
SLC41–48
(41): (42): (43):
Na+ -independent, system-L like amino-acid transporter
(44): (45):
Putative sugar transporter
(46): (47): (48):