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![]() | A fact from this article appeared on Wikipedia's Main Page in the "Did you know?" column on November 22, 2010. The text of the entry was: Did you know ... that methoxyflurane, an emergency analgesic self-administered with a disposable inhaler, was first synthesized as a by-product of chemistry research on uranium enrichment in the Manhattan Project? |
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"the field of halogen chemistry [...] was poorly understood until around 1940." This sentence is complete rubbish.
Prior to the Manhattan project fluorine chemistry was a very specialized area of chemistry because both fluorine and hydrogen fluoride were (and still are) very difficult to handle (corrosive, toxic etc.). During the Manhattan project alloys were developed so that these compounds could be used on an industrial scale to prepare uranium hexafluoride for the isotope separation plant. The ready availability of fluorine led to renewed interest in organo-fluorine chemistry, which was underdeveloped relative to organo-chorine chemistry at that time. Petergans (talk) 19:30, 22 November 2010 (UTC)
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Reviewer: Tea with toast (話) 21:58, 11 June 2011 (UTC)
1) In the "Biodegradation" section, there is a link to diuresis, which is a disambiguation page. I believe it should be directed to polyuria, but rather than make the change myself, I thought I would let you make the change in case you believe it should be otherwise.
2) There are several problems relating to the references. The following items have broken links:
Additionally, I think it would be helpful to have doi/pmid id links to many of the items listed under "Further readings". Some tools you might find useful: Template:Cite pmid, Template:Cite doi. They make citing references so much easier!
I will place this article on-hold until these reference issues can be sorted out. If you have any other questions, let me know. --Tea with toast (話) 22:55, 11 June 2011 (UTC)
GA review – see WP:WIAGA for criteria
I was on the Twitter today and noticed that the New York City EMS website had posted an update. Apparently, methoxyflurane has continued to be used, just as the Wikipedia article says, as an anesthetic agent in Australia/ New Zealand. However, there is a new financial deal which will expand use of it in Europe, see Australia's pain relieving 'green whistle' is closing in on a $70 million deal in Europe (29 June 2015). Selectively quoting, emphasis mine:
Medical Developments International, the company behind Australia’s “green whistle” pain relief inhaler, is near to closing a $US54.5 million licensing deal in Europe. The company says it has signed a term sheet and will now move to contract with an as-yet unnamed “significant pharmaceutical” group with expertise in pain management products to distribute Penthrox, the Melbourne-made emergency pain killer... it will be responsible for investing into the development of Penthrox and registering Penthrox throughout Europe... Medical Developments International is using a new lower cost manufacturing process developed with the CSIRO to increase production of Penthrox’s underlying drug methoxyflurane by ten-fold.
Shares of the company, Medical Developments Int'l, are up 12% in one day. That means that there will be lots of interest in this Wikipedia article. I am not suggesting that we add the Business Insider news story as a link to the article. I mention this only as a heads up to editors.
Personally, I am kind of curious why the nephrotoxicity issues are not receiving more attention, but that is neither here nor there for now.
One other aside: This is a GREAT Wikipedia article! Analytical chemists, no, chemistry professionals in general, are AWESOMELY thorough! --FeralOink (talk) 23:30, 29 June 2015 (UTC)
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