The urethral or periurethral glands (also Littré glands after Alexis Littré)^[1] are glands that branch off the wall of the urethra of mammals. The glands secrete mucus^[2] and are most numerous in the section of the urethra that runs through the penis. Urethral glands produce a colloid secretion containing glycosaminoglycans; this secretion protects the epithelium against urine.^[3]

Untreated urethritis can lead to infection of the urethral glands, which can in turn result in impeding urethral strictures.