Frederick Gowland Hopkins

Born(1861-06-20)20 June 1861
Eastbourne, Sussex, England
Died16 May 1947(1947-05-16) (aged 85)
Cambridge, England
EducationCity of London School
Alma materKing's College London
Guy's Hospital
Known forVitamins, tryptophan, glutathione
Awards
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Cambridge
Academic advisorsThomas Stevenson
Sir Michael Foster
Doctoral studentsJudah Hirsch Quastel
Malcolm Dixon
Antoinette Pirie
Other notable studentsJ.B.S. Haldane
Albert Szent-Györgyi[2]

Sir Frederick Gowland Hopkins OM FRS[3] (20 June 1861 – 16 May 1947) was an English biochemist who was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins. He also discovered the amino acid tryptophan, in 1901. He was President of the Royal Society from 1930 to 1935.[4]

Education and early life

Hopkins was born in Eastbourne, Sussex, and initially attended the City of London School. However, he soon transferred to Alexandra Park College in Hornsey[5] and completed his further study with the University of London External Programme (through evening classes at Birkbeck College) and the medical school at Guy's Hospital which is now part of King's College London School of Medicine.[6]

Career and research

After graduating, Hopkins then taught physiology and toxicology at Guy's Hospital from 1894 to 1898.[6] In 1898, while attending a meeting of the Physiological Society, he was invited by Sir Michael Foster to join the Physiological Laboratory in Cambridge to investigate the chemical aspects of physiology. Biochemistry was not, at that time, recognised as a separate branch of science.[6] He was a lecturer in chemical physiology at Emmanuel College, Cambridge in March 1900, when he received the academic rank Master of Arts (MA) honoris causa.[7] He earned a doctorate in physiology (D.Sc.) from the University of London in July 1902,[8] and at the same time was given a readership in biochemistry at Trinity College.[9] While at Cambridge he was initiated into Freemasonry.[10] In 1910 he became a Fellow of Trinity College, and an Honorary Fellow of Emmanuel College. In 1914 he was elected to the Chair of Biochemistry at Cambridge University, thus becoming the first Professor in that discipline at Cambridge.[11] His Cambridge students included neurochemistry pioneer Judah Hirsch Quastel and pioneer embryologist Joseph Needham.

Hopkins had for a long time studied how cells obtain energy via a complex metabolic process of oxidation and reduction reactions. His study in 1907 with Sir Walter Morley Fletcher of the connection between lactic acid and muscle contraction was one of the central achievements of his work on the biochemistry of the cell.[6] He and Fletcher showed that oxygen depletion causes an accumulation of lactic acid in the muscle.[12] Their work paved the way for the later discovery by Archibald Hill and Otto Fritz Meyerhof that a carbohydrate metabolic cycle supplies the energy used for muscle contraction.[12]

In 1912 Hopkins published the work for which he is best known, demonstrating in a series of animal feeding experiments that diets consisting of pure proteins, carbohydrates, fats, minerals, and water fail to support animal growth. This led him to suggest the existence in normal diets of tiny quantities of as yet unidentified substances that are essential for animal growth and survival. These hypothetical substances he called "accessory food factors", later renamed vitamins.[13] It was this work that led his being awarded (together with Christiaan Eijkman) the 1929 Nobel Prize in Physiology or Medicine.[6]

During World War I, Hopkins continued his work on the nutritional value of vitamins. His efforts were especially valuable in a time of food shortages and rationing. He agreed to study the nutritional value of margarine and found that it was, as suspected, inferior to butter because it lacked the vitamins A and D. As a result of his work, vitamin-enriched margarine was introduced in 1926.[6]

Hopkins is credited with the discovery and characterisation in 1921 of glutathione extracted from various animal tissues.[14] At the time he proposed that the compound was a dipeptide of glutamic acid and cysteine. The structure was controversial for many years but in 1929 he concluded that it was a tripeptide of glutamic acid, cysteine and glycine.[15] This conclusion agreed with that from the independent work of Edward Calvin Kendall.[16]

Awards and honours

Hopkins was elected a Foreign Associate of the National Academy of Sciences (USA) in 1924.[1] During his life, in addition to the Nobel Prize, Hopkins was awarded the Royal Medal of the Royal Society in 1918, the Cameron Prize for Therapeutics of the University of Edinburgh in 1922, and the Copley Medal of the Royal Society in 1926.[6]

Other significant honours were his election in 1905 as a Fellow of the Royal Society (FRS), Great Britain's most prestigious scientific organisation; his knighthood by King George V in 1925; and the award in 1935 of the Order of Merit, Great Britain's most exclusive civilian honour.

From 1930 to 1935, he served as president of the Royal Society and, in 1933, served as president of the British Association for the Advancement of Science.[6] He was elected to the American Philosophical Society in 1937.[17]

Personal life

In 1898, he married Jessie Anne Stephens (1861–1937); they had one son and two daughters, the younger of whom, Jacquetta Hawkes, became a prominent archaeologist[18] and married the author J. B. Priestley.[19]

Gowland Hopkins died on 16 May 1947 in Cambridge and is buried at the Parish of the Ascension Burial Ground in Cambridge, with his wife.[20][21]

See also

References

  1. ^ a b "Frederick Hopkins".
  2. ^ Szent-Györgyi, Albert (1929). Observations on the functions of peroxidase systems and the chemistry of the adrenal cortex. jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 1063377732. EThOS uk.bl.ethos.648034.
  3. ^ Dale, Henry Hallett (1948). "Frederick Gowland Hopkins. 1861–1947". Obituary Notices of Fellows of the Royal Society. 6 (17): 115–126. doi:10.1098/rsbm.1948.0022. S2CID 177244789.
  4. ^ Online catalogue of Hopkins' personal and working papers (part of the Manuscript collections held at Cambridge University Library)
  5. ^ Certificate from the college shown on Harringay Online
  6. ^ a b c d e f g h Needham, J. (1962). "Sir Frederick Gowland Hopkins, O.M., F.R.S. (1861–1947)". Notes and Records of the Royal Society. 17 (2): 117–126. doi:10.1098/rsnr.1962.0014. S2CID 145795016.
  7. ^ "University intelligence". The Times. No. 36081. London. 5 March 1900. p. 11.
  8. ^ "University intelligence". The Times. No. 36829. London. 25 July 1902. p. 5.
  9. ^ "University intelligence". The Times. No. 36783. London. 2 June 1902. p. 9.
  10. ^ "Freemasons and the Royal Society" (PDF). Archived from the original (PDF) on 24 December 2018. Retrieved 2 January 2019.
  11. ^ "Hopkins, Frederick Gowland (HPKS900FG)". A Cambridge Alumni Database. University of Cambridge.
  12. ^ a b Barclay CJ, Curtin NA (April 2022). "The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics". J Physiol. 600 (7): 1555–1578. doi:10.1113/JP281556. PMC 9304278. PMID 35114037.
  13. ^ Hopkins, F. G. (1912). "Feeding experiments illustrating the importance of accessory factors in normal dietaries". The Journal of Physiology. 44 (5–6): 425–460. doi:10.1113/jphysiol.1912.sp001524. PMC 1512834. PMID 16993143.
  14. ^ Simoni, R. D.; Hill, R. L.; Vaughan, M. (2002). "On glutathione. II. A thermostable oxidation-reduction system (Hopkins, F. G., and Dixon, M. (1922) J. Biol. Chem. 54, 527–563)". The Journal of Biological Chemistry. 277 (24): e13. PMID 12055201.
  15. ^ Hopkins, Frederick Gowland (1929). "On Glutathione: A Reinvestigation" (PDF). J. Biol. Chem. 84: 269–320. doi:10.1016/S0021-9258(18)77062-2.
  16. ^ Kendall, Edward C.; McKenzie, Bernard F.; Mason, Harold L. (1929). "A Study of Glutathione. I. Its Preparation in Crystalline Form and its Identification". J. Biol. Chem. 84 (2): 657–674. doi:10.1016/S0021-9258(18)77022-1.
  17. ^ "APS Member History". search.amphilsoc.org. Retrieved 24 May 2023.
  18. ^ Cooke, Rachel (2013). Her Brilliant Career - Ten Extraordinary Women of the 1950s. Great Britain: Virago. pp. 219–257. ISBN 9781844087419.
  19. ^ J.B. Priestley, The Edwardians (New York: Harper & Row, 197), p. 243.
  20. ^ A Guide to Churchill College, Cambridge: text by Dr. Mark Goldie, pp. 62-63 (2009)
  21. ^ Trinity College Chapel. Accessed 24 January 2023.
Professional and academic associations Preceded byErnest Rutherford 45th President of the Royal Society 1930–1935 Succeeded byWilliam Henry Bragg