Irritability is the excitatory ability that living organisms have to respond to changes in their environment. The term is used for both the physiological reaction to stimuli and for the pathological, abnormal or excessive sensitivity to stimuli.[1]

When reflecting human emotion and behavior, it is commonly defined as the tendency to react to stimuli with negative affective states (especially anger) and temper outbursts, which can be aggressive. Distressing or impairing irritability is important from a mental health perspective as a common symptom of concern and predictor of clinical outcomes.[2]


Irritability is the excitatory ability that living organisms have to respond to changes in their environment.[1] The term is used for both the physiological reaction to stimuli and for the pathological, abnormal or excessive sensitivity to stimuli. Irritability can be demonstrated in behavioral responses to both physiological and behavioral stimuli, including environmental, situational, sociological, and emotional stimuli.

In humans, irritability may be a significant transdiagnostic symptom or disposition that occurs across or at any point during the lifespan.[3] It is commonly defined as the tendency to react to stimuli with the experience of negative affective states (especially anger) and temper outbursts, which may or may not be aggressive.[4][5][6] This definition is well known to have similarities with the definitions of anger and aggression. New hypotheses[6][7] and data-driven research[8] are focused on identifying what is unique to irritability, anger, and aggression. The definition is broad. It is also consistent with special definitions that are relevant to research and treatment. One definition is that irritability is a low threshold for experiencing frustration.[9] This definition is helpful for experiments because researchers can induce frustration by blocking desired rewards or doling out unexpected punishments. However, it is not particularly specific to irritability, as frustration is its own construct with a number of emotional and behavioral associations.[10][11] A second prominent special definition describes a group of behavioral issues often occurring in those diagnosed with an autism spectrum disorder.[12] This deserves mention here because this version of irritability has been a commonly used in a number of clinical trials and defines the current US Food and Drug Administration irritability indication.

Signs and symptoms

As an emotional and behavioral symptom in humans, someone is considered to be irritable when they have a short temper, become easily frustrated, or feel grouchy or grumpy. Caregivers may report tension in the household or fatigue. They may make accommodations to avoid provoking their dependents. Irritability is associated with a number of mental health conditions.[13] It is a defining characteristic of any mood disorder, such as bipolar, depressive, and disruptive mood dysregulation disorders.[13] It is also a major feature of a number of other disorders, including autism spectrum disorders, traumatic stress disorders, generalized anxiety disorder, etc.[6] Finally, it is a notable characteristic of delirium, dementia, hormonal change, metabolic disturbance, chronic stress, pain, and substance/medication withdrawal.[14]

Of course, given that irritability is not specific to any one condition, clinicians consider biological, social, psychological, and familial factors. Irritability may be an indicator of diagnosis, course of illness, or prognosis. For example, a major concern for clinicians is the time course of irritability. If a person presents as uncharacteristically irritable, then a clinician may become concerned a change or episodic illness, such as a neurologic insult or mood disorder. Understanding the time course of irritability is critical for establishing the diagnosis of pediatric bipolar disorder from disruptive mood dysregulation disorder.[15] In another example, chronic, severe irritability in older children (not including young children, e.g. preschool age, where normative irritability may be severe)[16] may predict later depression and anxiety[2] and suicidality.[17][18][19]


Several major neural systems have been implicated across a number of studies for idiopathic, chronic irritability.[20] These include the following: 1) prefrontal areas that underlying complex, goal directed behavior, especially inhibitory control and the regulation of emotions; 2) cortico-subcortical systems underlying reward processing, particularly in reaction to a frustrating stimulus; and 3) cortico-subcortical systems underlying threat and arousal processing, particularly in the context of social fairness or social threat.

See also


  1. ^ a b D, Venes (2013). Taber's Cyclopedic Medical Dictionary. Philadelphia, Pennsylvania: F.A. Davis Company. ISBN 978-0-8036-2977-6.
  2. ^ a b Vidal-Ribas, Pablo; Brotman, Melissa A.; Valdivieso, Isabel; Leibenluft, Ellen; Stringaris, Argyris (2016). "The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review". Journal of the American Academy of Child & Adolescent Psychiatry. 55 (7): 556–570. doi:10.1016/j.jaac.2016.04.014. ISSN 0890-8567. PMC 4927461. PMID 27343883.
  3. ^ Eshel, Neir; Leibenluft, Ellen (2019-12-04). "New Frontiers in Irritability Research—From Cradle to Grave and Bench to Bedside". JAMA Psychiatry. 77 (3): 227–228. doi:10.1001/jamapsychiatry.2019.3686. PMID 31799997. S2CID 208621875.
  4. ^ Caprara, G.V.; Cinanni, V.; D'Imperio, G.; Passerini, S.; Renzi, P.; Travaglia, G. (1985). "Indicators of impulsive aggression: Present status of research on irritability and emotional susceptibility scales". Personality and Individual Differences. 6 (6): 665–674. doi:10.1016/0191-8869(85)90077-7. ISSN 0191-8869.
  5. ^ Holtzman, Susan; O'Connor, Brian P.; Barata, Paula C.; Stewart, Donna E. (2014-05-15). "The Brief Irritability Test (BITe)". Assessment. 22 (1): 101–115. doi:10.1177/1073191114533814. ISSN 1073-1911. PMC 4318695. PMID 24830513.
  6. ^ a b c Toohey, Michael J.; DiGiuseppe, Raymond (April 2017). "Defining and measuring irritability: Construct clarification and differentiation". Clinical Psychology Review. 53: 93–108. doi:10.1016/j.cpr.2017.01.009. PMID 28284170.
  7. ^ Beauchaine, Theodore P.; Tackett, Jennifer L. (2020). "Irritability as a Transdiagnostic Vulnerability Trait:Current Issues and Future Directions". Behavior Therapy. 51 (2): 350–364. doi:10.1016/j.beth.2019.10.009. ISSN 0005-7894. PMID 32138943. S2CID 212565146.
  8. ^ Bettencourt, B. Ann; Talley, Amelia; Benjamin, Arlin James; Valentine, Jeffrey (2006). "Personality and aggressive behavior under provoking and neutral conditions: A meta-analytic review". Psychological Bulletin. 132 (5): 751–777. doi:10.1037/0033-2909.132.5.751. ISSN 1939-1455. PMID 16910753. S2CID 10793794.
  9. ^ Malhi, Gin; Bell, Erica; Outhred, Tim (2019-06-27). "Getting irritable about irritability?". Evidence-Based Mental Health. 22 (3): 93–94. doi:10.1136/ebmental-2019-300101. ISSN 1362-0347. PMC 10270366. PMID 31248977.
  10. ^ Berkowitz, Leonard (1989). "Frustration-aggression hypothesis: Examination and reformulation". Psychological Bulletin. 106 (1): 59–73. doi:10.1037/0033-2909.106.1.59. ISSN 1939-1455. PMID 2667009.
  11. ^ "NIMH " Construct: Frustrative Nonreward". Retrieved 2020-04-10.
  12. ^ Kaat, Aaron J.; Lecavalier, Luc; Aman, Michael G. (2013-10-29). "Validity of the Aberrant Behavior Checklist in Children with Autism Spectrum Disorder". Journal of Autism and Developmental Disorders. 44 (5): 1103–1116. doi:10.1007/s10803-013-1970-0. ISSN 0162-3257. PMID 24165702. S2CID 254571975.
  13. ^ a b Diagnostic and statistical manual of mental disorders : DSM-5. American Psychiatric Association., American Psychiatric Association. DSM-5 Task Force. (5th ed.). Arlington, VA: American Psychiatric Association. 2013. ISBN 978-0-89042-554-1. OCLC 830807378.((cite book)): CS1 maint: others (link)
  14. ^ Stringaris, Argyris (5 March 2015). Disruptive mood : irritability in children and adolescents. Taylor, Eric. Oxford. ISBN 978-0-19-166205-8. OCLC 905544004.((cite book)): CS1 maint: location missing publisher (link)
  15. ^ Towbin, Kenneth; Axelson, David; Leibenluft, Ellen; Birmaher, Boris (2013). "Differentiating Bipolar Disorder–Not Otherwise Specified and Severe Mood Dysregulation". Journal of the American Academy of Child & Adolescent Psychiatry. 52 (5): 466–481. doi:10.1016/j.jaac.2013.02.006. ISSN 0890-8567. PMC 3697010. PMID 23622848.
  16. ^ Wiggins, Jillian Lee; Mitchell, Colter; Stringaris, Argyris; Leibenluft, Ellen (2014). "Developmental Trajectories of Irritability and Bidirectional Associations With Maternal Depression". Journal of the American Academy of Child & Adolescent Psychiatry. 53 (11): 1191–1205.e4. doi:10.1016/j.jaac.2014.08.005. ISSN 0890-8567. PMC 4254549. PMID 25440309.
  17. ^ Pickles, A.; Aglan, A.; Collishaw, S.; Messer, J.; Rutter, M.; Maughan, B. (2009-11-26). "Predictors of suicidality across the life span: The Isle of Wight study" (PDF). Psychological Medicine. 40 (9): 1453–1466. doi:10.1017/s0033291709991905. ISSN 0033-2917. PMID 19939326. S2CID 8465693.
  18. ^ Conner, Kenneth R.; Meldrum, Sean; Wieczorek, William F.; Duberstein, Paul R.; Welte, John W. (2004). "The Association of Irritability and Impulsivity with Suicidal Ideation Among 15- to 20-year-old Males". Suicide and Life-Threatening Behavior. 34 (4): 363–373. doi:10.1521/suli.34.4.363.53745. ISSN 0363-0234. PMID 15585458.
  19. ^ Brezo, J.; Paris, J.; Turecki, G. (2006). "Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review". Acta Psychiatrica Scandinavica. 113 (3): 180–206. doi:10.1111/j.1600-0447.2005.00702.x. ISSN 0001-690X. PMID 16466403. S2CID 12219596.
  20. ^ Brotman, Melissa A.; Kircanski, Katharina; Stringaris, Argyris; Pine, Daniel S.; Leibenluft, Ellen (2017). "Irritability in Youths: A Translational Model". American Journal of Psychiatry. 174 (6): 520–532. doi:10.1176/appi.ajp.2016.16070839. ISSN 0002-953X. PMID 28103715.