miR-208 | |
---|---|
Identifiers | |
Symbol | miR-208 |
Alt. Symbols | MIR208 |
Rfam | RF00749 |
miRBase | MI0000251 |
miRBase family | MIPF0000178 |
NCBI Gene | 406990 |
HGNC | 31585 |
OMIM | 611116 |
RefSeq | NR_029595 |
Other data | |
RNA type | miRNA |
Domain(s) | Metazoa |
GO | 0035195 |
SO | 0001244 |
Locus | Chr. 14 q11.2 |
PDB structures | PDBe |
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
In humans, the gene for miR-208 is located in an intron of MYH7.[3]
miR-208 has been deemed a "myomiR"[3] as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133.[3] miR-208 is thought to be dysregulated in various cardiovascular diseases.[4][5]
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development.[3] It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.[6]
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy.[7] Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.[8]