Ovandrotone albumin
Combination of
OvandrotoneAndrostane steroid
Human serum albuminSerum protein
Clinical data
Trade namesFecundin, Ovastim
Other namesPolyandroalbumin; GR-33207; Ovandrotone:human serum albumin conjugate
AHFS/Drugs.comMonograph
Legal status
Legal status
Identifiers
ChemSpider
  • None

Ovandrotone albumin (INN, BAN) (brand names Fecundin, Ovastim),[1] also known as polyandroalbumin, as well as ovandrotone:human serum albumin conjugate, is an immunogen and vaccine against androstenedione that is used in veterinary medicine to increase the ovulation rate and number of lambs born to ewes.[2][3][4][5] It is a conjugate of ovandrotone (androstenedione-7α-carboxyethylthioether)[6] and human serum albumin.[5] The drug was developed by 1981 and was introduced in Australia and New Zealand in 1983.[4][7]

Ovandrotone albumin produces transient immunity against androstenedione,[8] and the generation of antibodies against androstenedione presumably decreases circulating levels of androstenedione.[7] This is thought to result in reduced negative feedback on the hypothalamic-pituitary-gonadal axis and increased gonadotropin secretion, which in turn improves fertility and fecundity.[4] Indeed, ovandrotone albumin has been found to significantly increase luteinizing hormone levels throughout the estrous cycle in ewes.[4]

See also

References

  1. ^ Sylvester-Bradley R, Wiseman J (1 January 2005). Yields of Farmed Species: Constraints and Opportunities in the 21st Century. Nottingham University Press. p. 55. ISBN 978-1-904761-23-5.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 908. ISBN 978-1-4757-2085-3.
  3. ^ Hoskinson RM, Scaramuzzi RJ, Campbell BK, Downing JA, Welch RJ, Harrison BE (1986). "Effects of Antibodies to Steroid Hormones on Reproductive Events of Sheep and Cattle". Immunological Approaches to Contraception and Promotion of Fertility. pp. 351–366. doi:10.1007/978-1-4684-5140-5_38. ISBN 978-1-4684-5142-9.
  4. ^ a b c d Carnegie PR (1988). "Autoimmunization Against Hormones: A New Strategy in Animal Production". Anti-Idiotypes, Receptors, and Molecular Mimicry. pp. 245–254. doi:10.1007/978-1-4612-3734-1_15. ISBN 978-1-4612-8325-6.
  5. ^ a b International Nonproprietary Names (INN) for biological and biotechnological substances
  6. ^ Journal of Animal Science. American Society of Animal Science. 1991. pp. 3931–3932.
  7. ^ a b Sreenan JM, Diskin MG (6 December 2012). Embryonic Mortality in Farm Animals. Springer Science & Business Media. pp. 172–. ISBN 978-94-009-5038-2.
  8. ^ Lindsay DR, Pearce DT, eds. (1984). Reproduction in Sheep. Cambridge University Press.