Epitiostanol is used as an antiestrogen and antineoplastic agent in the treatment of breast cancer.[1][2][3][4][5] It has also been found to be effective in the treatment of gynecomastia.[6][7]
^ abcdMatsuzawa A, Yamamoto T (December 1977). "Antitumor effect of two oral steroids, mepitiostane and fluoxymesterone, on a pregnancy-dependent mouse mammary tumor (TPDMT-4)". Cancer Research. 37 (12): 4408–4415. PMID922732.
^Kurachi K, Aono T, Tomoyama J, Matsumoto K, Nakasima A (January 1975). "Effects of 2alpha, 3alpha-epithio-5alpha-androstan-17beta-ol (epitiostanol) on hypothalamo-pituitary-gonadal axis in humans". Acta Obstetrica et Gynaecologica Japonica. Japanese Obstetrical and Gynecological Society. 22 (1): 42–8. PMID1224948.
^ abAbe O, Kumaoka S, Yamamoto H (December 1973). "2α 3α-Epithio-5α-androstan-17β-ol in Treatment of Gynecomastia". Japanese Journal of Clinical Oncology. 3 (2): 99–104. doi:10.1093/oxfordjournals.jjco.a039832. ISSN1465-3621.
^Inoue K, Okazaki K, Morimoto T, Hayashi M, Uyama S, Sonoo H, et al. (May 1978). "Therapeutic value of mepitiostane in the treatment of advanced breast cancer". Cancer Treatment Reports. 62 (5): 743–745. PMID657160.
^ abIchihashi T, Kinoshita H, Yamada H (July 1991). "Absorption and disposition of epithiosteroids in rats (2): Avoidance of first-pass metabolism of mepitiostane by lymphatic absorption". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 21 (7): 873–880. doi:10.3109/00498259109039527. PMID1776263.
^Ichihashi T, Kinoshita H, Takagishi Y, Yamada H (October 1991). "Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine". Pharmaceutical Research. 8 (10): 1302–1306. doi:10.1023/A:1015864131681. PMID1796049. S2CID31203405.
^Ichihashi T, Takagishi Y, Yamada H (December 1992). "Factors determining the intrinsic lymphatic partition rate of epitiostanol and mepitiostane". Pharmaceutical Research. 9 (12): 1617–1621. doi:10.1023/A:1015824710957. PMID1488406. S2CID2881279.