11 August – Alejandro Giammattei wins the second round of the presidential elections with 58% of the vote, defeating Sandra Torres, wife of the current president.[2]
14 May – Wilmer Josue Ramirez Vasquez, 2, Guatemalan refugee who died while in the custody of U.S. Immigration and Customs Enforcement in El Paso, Texas; multiple intestinal and respiratory infectious diseases[6]
25 September – Michael Coe, 90, American archaeologist and anthropologist who worked in Guatemala and Mexico (b. 1929)[7]
1 November – Rina Lazo, 93, muralist (Fertile Earth), painter, and activist in Guatemala (Order of the Quetzal, 2004) and Mexico (b. Guatemala City, 1923)[8]