OUP-16
OUP-16.svg
Names
IUPAC name
1-cyano-3-[[(2R,5R)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C11H16N6O/c1-13-11(16-6-12)15-4-8-2-3-10(18-8)9-5-14-7-17-9/h5,7-8,10H,2-4H2,1H3,(H,14,17)(H2,13,15,16)/t8-,10-/m1/s1
    Key: CCOQWVUQXNRKKP-PSASIEDQSA-N
  • CN=C(NC[C@H]1CC[C@@H](O1)C2=CN=CN2)NC#N
Properties
C11H16N6O
Molar mass 248.290 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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OUP-16 is a histamine agonist selective for the H4 subtype.[1]

References

  1. ^ Hashimoto, T; Harusawa, S; Araki, L; Zuiderveld, OP; Smit, MJ; Imazu, T; Takashima, S; Yamamoto, Y; Sakamoto, Y; Kurihara, T; Leurs, R; Bakker, RA; Yamatodani, A (July 2003). "A Selective Human H4-Receptor Agonist: (−)-2-Cyano-1-methyl-3-{(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine". Journal of Medicinal Chemistry. 46 (14): 3162–5. doi:10.1021/jm0300025. PMID 12825954.