Clinical data
Trade namesTofranil, Tofranil-PM, others
Other namesMelipramine; G-22355
License data
Routes of
By mouth, intramuscular injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding86%[3]
MetabolismLiver (CYP1A2, CYP2C19, CYP2D6)[3]
Elimination half-life20 hours[3]
ExcretionKidney (80%), fecal (20%)[3]
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
CAS Number
PubChem CID
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.000.039 Edit this at Wikidata
Chemical and physical data
Molar mass280.415 g·mol−1
3D model (JSmol)
  • CN(C)CCCN1c2ccccc2CCc2ccccc21
  • InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 checkY

Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression. It is also effective in treating anxiety and panic disorder. Imipramine may also be used off-label for nocturnal enuresis and chronic pain. Imipramine is taken by mouth.

Common side effects of imipramine include dry mouth, drowsiness, dizziness, low blood pressure, rapid heart rate, urinary retention, and electrocardiogram changes. Overdose of the medication can result in death. Imipramine appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors.

Imipramine was discovered in 1951 and was introduced for medical use in 1957. It was the first TCA to be marketed. Imipramine and the other TCAs have decreased in use in recent decades, due to the introduction of the selective serotonin reuptake inhibitors (SSRIs), which have fewer side effects and are far safer in overdose.

Medical uses

Imipramine is used in the treatment of depression and certain anxiety disorders. It is similar in efficacy to the antidepressant drug moclobemide.[4] It has also been used to treat nocturnal enuresis because of its ability to shorten the time of delta wave stage sleep, where wetting occurs. In veterinary medicine, imipramine is used with xylazine to induce pharmacologic ejaculation in stallions. Blood levels between 150 and 250 ng/mL of imipramine plus its metabolite desipramine generally correspond to antidepressant efficacy.[5]

Available forms

Imipramine is available in the form of oral tablets and capsules.


Combining it with alcohol consumption causes excessive drowsiness. It may be unsafe during pregnancy.

Side effects

These side effects can be contributed to the multiple receptors that imipramine targets such as serotonin, norepinephrine, dopamine, acetylcholine, epinephrine, histamine. Those listed in italics below denote common side effects, separated by the organ systems that are affected.[6]


Main articles: Tricyclic antidepressant § Overdose, and Tricyclic antidepressant overdose


Main article: Tricyclic antidepressant § Interactions



See also: Pharmacology of antidepressants and Tricyclic antidepressant § Binding profiles

Imipramine (and metabolite)[7][8]
Site IMI DSI Species Ref
SERT 1.3–1.4 17.6–163 Human [9][10]
NET 20–37 0.63–3.5 Human [9][10]
DAT 8,500 3,190 Human [9]
5-HT1A ≥5,800 ≥6,400 Human [11][12][13]
5-HT2A 80–150 115–350 Human [11][13]
5-HT2C 120 244–748 Human/rat [14][15][12]
5-HT3 970–3,651 ≥2,500 Rodent [12][16]
5-HT6 190–209 ND Rat [17]
5-HT7 >1,000 >1,000 Rat [18]
α1 32 23–130 Human [11][19][10]
α2 3,100 ≥1,379 Human [11][19][10]
β >10,000 ≥1,700 Rat [20][21][22]
D1 >10,000 5,460 Human [12][23]
D2 620–726 3,400 Human [23][12][19]
D3 387 ND Human [12]
H1 7.6–37 60–110 Human [11][19][24]
H2 550 1,550 Human [24]
H3 >100,000 >100,000 Human [24]
H4 24,000 9,550 Human [24]
mACh 46 66–198 Human [11][19]
  M1 42 110 Human [25]
  M2 88 540 Human [25]
  M3 60 210 Human [25]
  M4 112 160 Human [25]
  M5 83 143 Human [25]
α3β4 410–970 ND Human [26]
σ1 332–520 1,990–4,000 Rodent [27][28][29]
σ2 327–2,100 ≥1,611 Rat [7][28][29]
hERG 3,400 ND Human [30]
Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site.

Imipramine affects numerous neurotransmitter systems known to be involved in the etiology of depression, anxiety, attention-deficit hyperactivity disorder (ADHD), enuresis and numerous other mental and physical conditions. Imipramine is similar in structure to some muscle relaxants, and has a significant analgesic effect and, thus, is very useful in some pain conditions.

The mechanisms of imipramine's actions include, but are not limited to, effects on:


Within the body, imipramine is converted into desipramine (desmethylimipramine) as a metabolite.


Imipramine is a tricyclic compound, specifically a dibenzazepine, and possesses three rings fused together with a side chain attached in its chemical structure.[35] Other dibenzazepine TCAs include desipramine (N-desmethylimipramine), clomipramine (3-chloroimipramine), trimipramine (2′-methylimipramine or β-methylimipramine), and lofepramine (N-(4-chlorobenzoylmethyl)desipramine).[35][36] Imipramine is a tertiary amine TCA, with its side chain-demethylated metabolite desipramine being a secondary amine.[37][38] Other tertiary amine TCAs include amitriptyline, clomipramine, dosulepin (dothiepin), doxepin, and trimipramine.[39][40] The chemical name of imipramine is 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine and its free base form has a chemical formula of C19H24N2 with a molecular weight of 280.407 g/mol.[41] The drug is used commercially mostly as the hydrochloride salt; the embonate (pamoate) salt is used for intramuscular administration and the free base form is not used.[41][42] The CAS Registry Number of the free base is 50-49-7, of the hydrochloride is 113-52-0, and of the embonate is 10075-24-8.[41][42]


The parent compound of imipramine, 10,11-dihydro-5H-dibenz[b,f]azepine (dibenzazepine), was first synthesized in 1899, but no pharmacological assessment of this compound or any substituted derivatives was undertaken until the late 1940s.[43][44][45] Imipramine was first synthesized in 1951, as an antihistamine.[46][47] The antipsychotic effects of chlorpromazine were discovered in 1952,[48] and imipramine was then developed and studied as an antipsychotic for use in patients with schizophrenia.[19][49] The medication was tested in several hundred patients with psychosis, but showed little effectiveness.[50] However, imipramine was serendipitously found to possess antidepressant effects in the mid-1950s following a case report of symptom improvement in a woman with severe depression who had been treated with it.[19][49][51] This was followed by similar observations in other patients and further clinical research.[52][50] Subsequently, imipramine was introduced for the treatment of depression in Europe in 1958 and in the United States in 1959.[53] Along with the discovery and introduction of the monoamine oxidase inhibitor iproniazid as an antidepressant around the same time, imipramine resulted in the establishment of monoaminergic drugs as antidepressants.[51][52][50]

In the late 1950s, imipramine was the first TCA to be developed (by Ciba). At the first international congress of neuropharmacology in Rome, September 1958 Dr Freyhan from the University of Pennsylvania discussed as one of the first clinicians the effects of imipramine in a group of 46 patients, most of them diagnosed as "depressive psychosis". The patients were selected for this study based on symptoms such as depressive apathy, kinetic retardation and feelings of hopelessness and despair. In 30% of all patients, he reported optimal results, and in around 20%, failure. The side effects noted were atropine-like, and most patients experienced dizziness. Imipramine was first tried for treating psychotic disorders such as schizophrenia, but proved ineffective. As an antidepressant, it did well in clinical studies and it is known to work well in even the most severe cases of depression.[54] It is not surprising, therefore, that imipramine may cause a high rate of manic and hypomanic reactions in hospitalized patients with pre-existing bipolar disorder, with one study showing that up to 25% of such patients maintained on Imipramine switched into mania or hypomania.[55] Such powerful antidepressant properties have made it favorable in the treatment of treatment-resistant depression.

Before the advent of selective serotonin reuptake inhibitors (SSRIs), its sometimes intolerable side-effect profile was considered more tolerable. Therefore, it became extensively used as a standard antidepressant and later served as a prototypical drug for the development of the later-released TCAs. Since the 1990s, it has no longer been used as commonly, but is sometimes still prescribed as a second-line treatment for treating major depression . It has also seen limited use in the treatment of migraines, ADHD, and post-concussive syndrome. Imipramine has additional indications for the treatment of panic attacks, chronic pain, and Kleine-Levin syndrome. In pediatric patients, it is relatively frequently used to treat pavor nocturnus and nocturnal enuresis.

Society and culture

Generic names

Imipramine is the English and French generic name of the drug and its INN, BAN, and DCF, while imipramine hydrochloride is its USAN, USP, BANM, and JAN.[41][42][56][57] Its generic name in Spanish and Italian and its DCIT are imipramina, in German is imipramin, and in Latin is imipraminum.[42][57] The embonate salt is known as imipramine pamoate.[42][57]

Brand names

Imipramine is marketed throughout the world mainly under the brand name Tofranil.[42][57] Imipramine pamoate is marketed under the brand name Tofranil-PM for intramuscular injection.[42][57][58]


Imipramine is available for medical use widely throughout the world, including in the United States, the United Kingdom, elsewhere in Europe, India, Brazil, South Africa, Australia, and New Zealand.[57]

Prescription trends

Between 1998 and 2017, along with amitriptyline, imipramine was the most commonly prescribed first antidepressant for children aged 5-11 years in England.[59]


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Further reading