Clinical data
Routes of
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
  • (1-methyl-2-phenoxy-ethyl)hydrazine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass166.224 g·mol−1

Phenoxypropazine (trade name Drazine) is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine family. It was introduced as an antidepressant in 1961, but was subsequently withdrawn in 1966 due to hepatotoxicity concerns.[1][2][3][4][5]

See also


  1. ^ LEAHY MR, ROSE JT, PLOWMAN R (April 1963). "A preliminary study of phenoxypropazine in the treatment of depression". The American Journal of Psychiatry. 119 (10): 986–7. doi:10.1176/ajp.119.10.986. PMID 13928824.
  2. ^ IMLAH NW (May 1963). "Preliminary report on phenoxypropazine". The American Journal of Psychiatry. 119 (11): 1091–2. doi:10.1176/ajp.119.11.1091. PMID 13956423.
  3. ^ ROSE JT, LEAHY MR, PLOWMAN R (October 1963). "A comparison of phenoxypropazine and amitriptyline in depression". The American Journal of Psychiatry. 120 (4): 393–5. doi:10.1176/ajp.120.4.393. PMID 14069469.
  4. ^ ROSE JT (March 1964). "Phenoxypropazine and chlordiazepoxide in depression". The American Journal of Psychiatry. 120 (9): 899–900. doi:10.1176/ajp.120.9.899. PMID 14129290.
  5. ^ MCWHINNEY IR, MORRELL DC (January 1965). "Treatment of mild endogenous depression with a monoamine oxidase inhibitor: a controlled trial in general practice". The Journal of the College of General Practitioners. 9 (1): 95–9. PMC 1878242. PMID 14254271.