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Clinical data | |
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Pregnancy category |
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Routes of administration | Oral |
ATC code |
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Identifiers | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.038.481 |
Chemical and physical data | |
Formula | C10H10N2O3 |
Molar mass | 206.201 g·mol−1 |
3D model (JSmol) | |
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Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of depression but is now no longer marketed.[2][3] It acts as a reversible monoamine oxidase inhibitor (RIMA) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter.[4][5][6][7][8]
Synthesis starts by reductive amination of salicylaldehyde and glycinamide to give 3. The synthesis is completed by reaction with phosgene and NaHCO3.
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5-HT1AR agonists | |
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GABAAR PAMs |
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Hypnotics | |
Gabapentinoids (α2δ VDCC blockers) | |
Antidepressants |
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Antipsychotics | |
Sympatholytics (Antiadrenergics) |
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Others | |
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Non-specific |
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Phenethylamines (dopamine, epinephrine, norepinephrine) |
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Tryptamines (serotonin, melatonin) |
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Histamine |
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