Clinical data | |
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Trade names | Pirazidol |
Routes of administration | Oral |
ATC code |
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Pharmacokinetic data | |
Bioavailability | 20–30% |
Protein binding | 95% |
Metabolism | hepatic |
Onset of action | 2 to 8 hours |
Elimination half-life | up to 8 days [1] |
Excretion | urine (50–70%), feces (25–45%) |
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Chemical and physical data | |
Formula | C15H18N2 |
Molar mass | 226.323 g·mol−1 |
3D model (JSmol) | |
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Pirlindole (Lifril, Pyrazidol) is mainly a reversible inhibitor of monoamine oxidase A (RIMA) and secondly a SNRI which was developed and is used in Russia as an antidepressant.[2] It is structurally and pharmacologically related to metralindole.
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5-HT1AR agonists | |
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GABAAR PAMs |
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Gabapentinoids (α2δ VDCC blockers) | |
Antidepressants |
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Sympatholytics (Antiadrenergics) |
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Others | |
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Non-specific |
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Phenethylamines (dopamine, epinephrine, norepinephrine) |
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Tryptamines (serotonin, melatonin) |
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Histamine |
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