Combination of | |
---|---|
Ipratropium bromide | Muscarinic antagonist |
Salbutamol | Short-acting β2-adrenergic agonist |
Clinical data | |
Trade names | Combivent, Duoneb, Breva, others |
AHFS/Drugs.com | Professional Drug Facts |
MedlinePlus | a601063 |
License data | |
Routes of administration | Inhalation |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
(verify) |
Ipratropium bromide/salbutamol, sold under the brand name Duoneb among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[3][4][5] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[3]
Common side effects include sore throat, muscle cramps, and nausea.[3] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[3] Safety in pregnancy is unclear.[6][3]
The combination was approved for medical use in the United States in 1996.[7] It is available as a generic medication.[4] In 2020, it was the 150th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[8][9]
Since Combivent contains a chlorofluorocarbon-based propellant, its use was discontinued in 2013 in the United States and other countries. This was because Chlorofluorocarbons (CFC) are attributed to depletion of the ozone layer.[10]
α1 |
| ||||
---|---|---|---|---|---|
α2 |
| ||||
β |
| ||||
mAChRsTooltip Muscarinic acetylcholine receptors |
| ||||
---|---|---|---|---|---|
Precursors (and prodrugs) | |||||